Clooney - known as a prominent critic of the Bush government - told the BBC that he had been "nailed" in the American media following his vocal opposition to ongoing conflict in Iraq.
He has previously claimed that one magazine even published a front cover of him with the word "traitor" across it.
The actor is currently in two Oscar-nominated films, Good Night, And Good Luck and Syriana, which both have a political message.
"I've been nailed in the American press as a traitor to my country because I said we should ask questions before we went to war," he told the BBC.
"But I never held a press conference saying 'this is what you should think'. I asked questions and said 'these are the questions that I believe I have the right to ask' - which is what our government was founded on."