Aspirin is a long history of antipyretic analgesics, was born March 6, 1899. Used to treat colds, fever, headache, toothache, joint pain, rheumatism, can inhibit platelet aggregation, surgery for the prevention and treatment of ischemic heart disease, angina, heart and lung infarction, cerebral thrombosis, used in blood vessel formation and bypass grafting.
Chemical Name: ASPIRIN
CAS: 50-78-2
SMILES: CC(=O)Oc1ccccc1C(=O)O
Molecular Formula: C9H8O4
Molecular Weight: 180.15742
Synonyms: Rhodine(7CI);Salicylic acid acetate (8CI);2-(Acetyloxy)benzoic acid;AC 5230;Acetophen;Acetysal;Acimetten;Acisal;Saletin;Solpyron;Supac;Temperal;Toldex;Trombyl;Yasta;o-(Acetyloxy)benzoic acid;Acetyl Salicylic Acid;Adiro;Asaflow;Asagran;Asatard;Ascoden 30;Ascriptin;Aspalon;Aspirdrops;Aspirin;Aspirin Protect 300;Aspirin-Direkt;Aspro;Aspropharm;Astrix;Benaspir;Bialpirinia;Caprin;Coricidin D;Dolean pH 8;Easprin;Ecotrin;Endosprin;Entericin;Ewin;Extren;Gelprin;
EINECS: 200-064-1
Density: 1.35
Melting Point: 134-136 ℃(lit.)
Boiling Point: 321.4 ℃ at 760 mmHg
Flash Point: 131.1 ℃
Solubility: water: 3.3 g/L (20 ℃)
Risk Codes: 22-36/37/38
Transportation: UN 1851
Nature Description: white needle-like or platy crystal or powder. The melting point of 135 ~ 140 ℃. Odorless, microstrip sour. Stable in dry air, slowly hydrolyze into salicylic acid and acetic acid in moist air. Soluble in ethanol, dissolved in ether and chloroform, slightly soluble in water, can be dissolved in sodium hydroxide solution or sodium carbonate solution, but at the same decomposition. The product 1g can be dissolved in 300ml water 5ml alcohol 10-15ml ether and 17ml chloroform.
Safety Instructions: S26: In case of contact with eyes, rinse immediately with plenty of water and hospital treatment; S36/37/39: Wear suitable protective clothing, gloves and protective glasses or face shields.
Hazard Symbols: Xn: harmful substances
Risk Codes: R22: Harmful if swallowed; R36/37/38: have a stimulating effect on the eyes, respiratory tract and skin.
Transport of Dangerous Goods Number: UN1851
Application: application of the earliest and most widely used and most common antipyretic analgesic anti-rheumatic drug. Has antipyretic, analgesic, anti-rheumatic and anti-platelet aggregation, and many other pharmacological effects, play the rapid efficacy, efficacy and stability, ultra-dose easy to diagnosis and treatment, and rarely allergic reactions. Commonly used in cold and fever, headache, neuralgia, joint pain, muscle pain, rheumatic fever, acute within the wet arthritis, rheumatoid arthritis and toothache. "National Essential Drugs List" included in the varieties of acetylsalicylic acid is the other drug intermediates.
Production methods: Salicylic acid acetylation derived: acetic anhydride (the feedstock in the reaction tank to 0.7889 times the total amount of salicylate), then add two-thirds of the amount of salicylic acid, and stir to heat up in the 81-82 ℃ reaction of 40-60min. Cooling to 81-82 ° C insulation reaction 2h. Check for free salicylic acid after passing, cooling to 13 ° C, precipitation crystallization, rejection filter, washing drying, air drying at 65-70 ° C, acetyl salicylic acid.