As early as 1853 Charles Gerhardt, salicylic acid and acetic anhydride synthesized acetylsalicylic acid, but no attention has been paid; 1898 German chemist Feihuofuman, synthetic, and for his father to treat rheumatism arthritis, excellent efficacy; 1899 by Theodore Dreiser introduced into clinical, and named aspirin. So far, aspirin has been applied a century, the medical history of the three classic one of the drugs, it still is the world's most widely used antipyretic, analgesic and anti-inflammatory drugs, but also as a comparison and evaluation of other drugs Standard preparations. Antithrombotic effect in vivo, can inhibit the platelet release reaction, inhibition of platelet aggregation, reduction of TXA2 generated. Clinically used to prevent the onset of cardiovascular and cerebrovascular diseases.
Aspirin in the 1898 listing, in recent years it also has the role of anti-platelet aggregation, and so re-aroused great interest. Aspirin and other salicylic acid derivatives and polyvinyl alcohol, cellulose acetate, etc. Containing Hydroxyl polymer melt esterification, its polymer, the resulting product of anti-inflammatory and antipyretic analgesics than free A aspirin is more long-lasting.
According to literature, said the inventor of aspirin was Felix Hoffman of Germany, but this invention, plays a very important role in a Jewish chemist Arthur Ai Xing Green. Artur Ai Xing Green's bitter story takes place in 1934-1949. In 1934, Felix Hoffman claimed that he invented aspirin. Then Germany is in the dark period of Nazi persecution of Jews intensified. In this case, the arrogant Nazi rulers more reluctant to recognize the inventor of aspirin in the fact that the Jews, so they would be wrong to wear the crown of the inventor Felix Hoffmann, a person's head. "Germanic racial superiority theory" laced with gold. Nazi rulers in order to block the mouth of Artur Ai Xing Green, also put into a concentration camp. After World War II, about 1949, Artur Ai Xing Green raised this issue, but he soon died. Since then, this matter will go down the drain. British physician, historian Walter Snyder twists and turns to get the license of Bayer AG, Germany, access to all files in the Bayer laboratory, and finally restore the hard facts of the history of the true face of this invention. He pointed out: the invention of aspirin, Artur Ai Xing Green contributed. The fact is that in 1897, Felix Hoffman is indeed the first synthesized the main substances constitute aspirin, but he is under the guidance of his superiors - the well-known chemist Arthur Ai Xing Green and completely Ai Xing Green technology routes only to be successful.