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コロナウィルスに感染すると臭いがわからなくなる症状の仕組みについての論文(2022.1.24公開)です。
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Non-cell autonomous disruption of nuclear architechttps://www.sciencedirect.com/science/article/abs/pii/S0092867422001350ture as a potential cause of COVID-19 induced anosmia
Abstract:
SARS-CoV-2 infects less than 1% of cells in the human body, yet it can cause severe damage in a variety of organs.
Thus, deciphering 解読 the non-cell autonomous effects of SARS-CoV-2 infection is imperative不可欠 for understanding the cellular and molecular disruption it elicits.
Neurological and cognitive defects are among the least understood symptoms of COVID-19 patients, with olfactory dysfunction 嗅覚障害 being their most common sensory deficit.
Here, we show that both in humans and hamsters SARS-CoV-2 infection causes widespread downregulation 発現低下 of olfactory receptors (OR) and of their signaling components.
This non-cell autonomous effect is preceded by a dramatic reorganization of the neuronal nuclear architecture, which results in dissipation of genomic compartments harboring OR genes.
Our data provide a potential mechanism by which SARS-CoV-2 infection alters the cellular morphology and the transcriptome of cells it cannot infect, offering insight to its systemic effects in olfaction and beyond.
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