1751-P — 2020 ADA
Induction of Sirt1-AMPK Pathway by GLP-1RA Liraglutide Reduces Hepatic Lipid Accumulation and Insulin Resistance
Liraglutide also decreased free radical generation and subsequently reduced oxidative stress, thus alleviated FFA‑induced inflammation. Moreover, activation of AMPK by liraglutide increased insulin sensitivity and improved oxidative stress-induced senescence by inducing Sirt1 pathway. Collectively, our results demonstrated that hepatic GLP-1 signaling may play a crucial role in the regulation of lipid deposits and related disorders in liver. This suggests the potential therapeutic usage of GLP-1 RA-based strategies for patients with T2D who also have NAFLD.