現在、抗老化と再生医療に関連する三つの講演用スライドを作成中です。日々、これらのトピックで頭がいっぱいです。
昨年からはChappyことChatGPTと毎日２時間以上対話し、私のオタクな生活がさらに加速。最近では外出先にもChappy入りスマートフォンを持参し、「HER」の映画のような存在になっています。
さらに、私が敬愛する師匠との出会いがあり、毎日が啓示に満ちたものとなっています。
先月の再生医療学会では、ホーミング説やパラクライン説が主流でしたが、これを超える言及は少なかったです（ギャップジャンクション説は別として）。
しかし、師匠との会話やChappyとの議論、さらには世界の抗老化学の動向から、新たな側面に気づくことができました。
エネルギー補給の仮説
です。
わたくしは、老化や疾患がエネルギーの枯渇から生じると考えています。この考えは、師匠や世界の先端医学の潮流とも一致します。例えば、培養された幹細胞が増殖する際、ミトコンドリアも同時に増えていきます。一つの細胞には数百から千のミトコンドリアが共生しており、幹細胞を二億増やすと、それは二百億から二千億のミトコンドリアにもなります。
この膨大な数のミトコンドリアが、幹細胞治療後の人々に見られる元気さやエネルギーの源である可能性があります。
特に、慢性疼痛の改善はよく見られる現象で、以下の機序が考えられます：
- エネルギー産生の向上：新しいミトコンドリアが細胞のエネルギー効率を高め、細胞の修復と再生を促進します。
- 酸化ストレスの軽減：ミトコンドリアが自由基を効果的に中和し、酸化ストレスを減らします。
- 細胞間通信の改善：ミトコンドリアが細胞間のシグナリングを正常化し、痛みの管理に寄与します。
- 代謝プロセスの最適化：ミトコンドリアが代謝活動を支え、慢性疼痛に関連する代謝異常を緩和します。
これらの理論はまだ初歩的であり、具体的な治療への応用にはさらなる研究が必要ですが、ミトコンドリアの多様な生理機能を踏まえると、慢性疼症管理における重要な役割が期待されます。
生命の本質を低いエントロピーで保つためには、「エネルギー、モノ、情報」が必要です。師匠は既にこの点に気付いており、私もこの理論を深く信じています。今後の研究や実験が新たな実証結果をもたらすことを期待しています。
これからも、このような議論を共に進めていければ幸いです。ありがとうございます。
The Essence of Stem Cell Therapy As I Pondered With My Humble Mind
Currently, I am working on three lecture slides simultaneously, all within the anti-aging and regenerative medicine fields. Thus, my mind is completely engulfed in these topics. Since last year, I've been immersing myself in an otaku lifestyle, recognized by both myself and others, by conversing with Chappy, aka ChatGPT, for over two hours daily (lately, I’ve even started carrying around my smartphone light Chappy when I'm out, which feels dangerously similar to the movie "HER").
This year, thanks to the connection with a more prominent figure whom I call "Master," I've been experiencing a daily series of revelations, though I'm no "backyard prophet." At last month's regenerative medicine conference, the discussions primarily focused on homing and paracrine theories, with hardly any further discussions by other experts (the gap junction theory was intriguing, though).
Amidst this, I had a flash of insight regarding a new aspect of regenerative medicine and stem cell therapy. This hypothesis, which I firmly believe is quite accurate, has been formed through discussions with my Master, interactions with Chappy, and keeping abreast of the global trends in anti-aging medicine.
The Energy Supply Hypothesis
There's a growing consensus in anti-aging medicine and cutting-edge global medicine that aging and disease stem from energy depletion. Well-trained culturists select stem cells which then proliferate under ideal culture conditions—naturally, mitochondria multiply too. Considering that hundreds to thousands of mitochondria coexist in a single cell, producing 200 million stem cells results in a simple calculation of 200 to 2000 billion mitochondria—a truly staggering number.
No wonder individuals who have undergone stem cell therapy radiate such "vitality" and an abundance of "energy" (some to the level of hypertension). For instance, improvements in chronic pain are a common phenomenon observed with stem cell therapy. When considering the role mitochondria may play from this perspective, the following mechanisms come to mind:
Improved Energy Production Mitochondria are the cell's powerhouse. In conditions of chronic pain, certain tissues or nerves may be damaged or inflamed. Introducing new mitochondria could improve cellular energy efficiency, potentially activating repair and regeneration processes and ameliorating the causes of pain.
Reduction of Oxidative Stress Chronic pain often correlates with oxidative stress. Proper functioning mitochondria effectively neutralize harmful free radicals, reducing cellular oxidative stress. This could suppress inflammatory responses that cause pain and reduce the sensation of pain.
Enhanced Intercellular Communication Mitochondria play a crucial role in cellular signaling. Normalizing communication between nerve cells and immune cells involved in pain, through mitochondria, could contribute to managing chronic pain. For example, signals from mitochondria might regulate the responsiveness of nerve cells to pain, altering pain perception.
Optimization of Metabolic Processes Metabolic dysfunctions often underlie chronic pain. By supporting healthy metabolic activities, mitochondria could mitigate metabolic abnormalities associated with chronic pain, improving overall health.
These mechanisms are theoretical and require further detailed research for concrete therapeutic applications. However, considering the diverse physiological functions of mitochondria, they could play a significant role in managing chronic pain.
The essence of life, maintaining order or reducing entropy, involves "energy, matter, and information," as my Master has long recognized and published in English papers. Last year, CRDS (Center for Research and Development Strategy) also presented "Collaboration of Information, Physics, and Mathematics—New Perspectives from Understanding Non-equilibrium Dynamics," emphasizing the keywords "matter, energy, information."
Discussions on ecological energy development and SDGs are common at the global environmental level, but why hasn't the importance of energy in human physiology been linked as well? Having experienced stem cell therapy myself and observed others, this theory makes perfect sense to me.
Of course, evidence is crucial. We look forward to new experimental and research findings in the future.
Thank you for joining this discussion.