@DCE-MRIと18F FDG-PETを用いた脊椎病変の鑑別能について。(Eur Spine J 29, 1061–1070 (2020).)
Ktrans, Kep, SUVmaxのいずれも良性・境界悪性・悪性で有意差なし、となっているが、malignant(19 metastases, eight primary plasmacytomas, four osteosarcomas, three lymphomas, two chordomas, and two other lesions)というのはさすがにheterogeneous過ぎて、もったいない印象がある。
DCE-MRI, DWI, FDG-PETの診断能比較や組み合わせての診断精度上昇というパターンは結構前からさまざまな部位でやられているが、脊椎病変ではまだ珍しいよう。
@Gruberi bursa(American Journal of Roentgenology. 2016;207: 386-391.)
https://www.ajronline.org/doi/full/10.2214/AJR.15.15955
"the Gruberi bursa was identified in 93% of ankles with a fluid collection at the dorsolateral ankle on ultrasound (prevalence of 2.2% [164/7378 ultrasound examinations]) and that the Gruberi bursa had characteristic
features of being unilocular, anechoic, and compressible on ultrasound and being located between the EDL and the talus."
女性で見られる頻度が高く、キツめの靴を履く傾向のためかもしれない、という考察あり。
@IDH-mutant astrocytomaにおけるCDKN2A/B homozygous deletionについて(ASCO daily news: January 14, 2021, Sani H. Kizilbash, MD, MPH)
https://dailynews.ascopubs.org/do/10.1200/ADN.20.200430/full/
"Patients with IDH–mutant WHO grade 2 or 3 astrocytoma are generally considered to have an expected OS of more than 10 years; however, the presence of CDKN2A/B homozygous deletion changes this prognosis to an expected OS of approximately 3 years."
"evaluation for CDKN2A/Bhomozygous deletion should be considered for all patients with IDH–mutant astrocytoma"
cIMPACT-NOWでとりわけ強調されている予後不良となる変異で、"Astrocytoma, IDH-mutant, WHO grade IV"という表現まで提唱されている。
