テレビ番組。
真実をキチンと伝えるか？
一般に売っている商品。
安全なモノばかり？
恐ろしいものばかり？
とある番組で
「歯の為に
フッ素入り歯磨き粉で
磨いた後は口をあまり
すすいではいけない」
と放送していました。
早速、ミギニナラエ‼️と
された方もいるでしょう。
フッ素は神経毒ですから。
子供の場合、
ＩＱの低下を認めています。
脳をとるか、歯をとるか？
Developmental
Fluoride Neurotoxicity:
A Systematic Review
and Meta-Analysis
Abstract
Supplemental Material
Background:
Although fluoride may cause
neurotoxicity in animal models
and acute fluoride poisoning
causes neurotoxicity in adults,
very little is known of its effects
on children’s neurodevelopment.
Objective:
We performed
a systematic review
and meta-analysis of
published studies
to investigate
the effects of
increased fluoride exposure
and delayed neurobehavioral development.
Methods:
We searched
the MEDLINE, EMBASE,
Water Resources Abstracts,
and TOXNET databases
through 2011 for eligible studies.
We also searched
the China National Knowledge Infrastructure (CNKI) database,
because many studies
on fluoride neurotoxicity
have been published
in Chinese journals only.
In total, we identified
27 eligible epidemiological studies
with high and reference exposures,
end points of IQ scores,
or related
cognitive function measures
with means and variances
for the two exposure groups.
Using random-effects models,
we estimated
the standardized
mean difference
between exposed
and reference groups
across all studies.
We conducted
sensitivity analyses
restricted to studies
using the same outcome assessment
and having
drinking-water fluoride
as the only exposure.
We performed
the Cochran test
for heterogeneity between studies,
Begg’s funnel plot,
and Egger test
to assess publication bias,
and conducted
meta-regressions
to explore sources
of variation in mean differences
among the studies.
Results:
The standardized weighted
mean difference in IQ score
between exposed
and reference populations
was –0.45
(95% confidence interval: –0.56, –0.35) using a random-effects model.
Thus, children
in high-fluoride areas
had significantly
lower IQ scores
than those
who lived
in low-fluoride areas.
Subgroup and sensitivity analyses
also indicated inverse associations, although the substantial heterogeneity
did not appear to decrease.
Conclusions:
The results support
the possibility
of an adverse effect
of high fluoride exposure
on
children’s neurodevelopment.
Future research should include
detailed individual-level information
on prenatal exposure,
neurobehavioral performance,
and covariates for adjustment.