白内障患者は1.48倍
（3.18 vs. 2.15）
パーキンソン病のリスク
が高まるとの事。
白内障とパーキンソン病を
結びつける要因として、
ミトコンドリア機能不全に
言及しています。
となれば、
予防策は無いわけでは無い。
Increased risk
of
Parkinson's disease
in cataract patients:
A population
-based
cohort study.
Authors
Lai SW1,
Lin CL2,
Liao KF3,
Chang-Ou KC4.
1School of Medicine,
China Medical University,
Taichung, Taiwan;
Department
of Family Medicine,
China Medical
University Hospital,
Taichung, Taiwan.
2Department of
Public Health,
China Medical University,
Taichung, Taiwan;
Management Office
for Health Data,
China Medical
University Hospital,
Taichung, Taiwan.
3Graduate Institute
of Integrated Medicine,
China Medical University,
Taichung, Taiwan;
Department
of Internal Medicine,
Taichung Tzu Chi
General Hospital,
Taichung,Taiwan.
4Department
of Internal Medicine,
Taichung Tzu Chi
General Hospital,
Taichung, Taiwan.
Journal
Parkinsonism Relat Disord.
2015 Jan;21(1):68-71.
doi: 10.1016/
j.parkreldis.2014.11.005.
Highlights
•Cataract patients
had a 1.48-fold higher
in the incidence
of Parkinson's disease
•Cataract patients
had a 26% increased hazard
of Parkinson's disease.
•Mitochondrial dysfunction
may play a key role in this issue.
The purpose of this study
was to investigate
whether there is an association
between cataracts
and Parkinson's disease
in Taiwan.
Methods
A retrospective cohort study
was conducted
to analyze the database
of the Taiwan National
Health Insurance Program
from 1999 to 2002.
This study consisted
of 26,031 individuals
aged 40–84 years
with newly diagnosed cataracts
as the cataract group
and 25,937
randomly selected individuals
without cataracts
as the non-cataract group.
Both groups were
matched for sex, age
and index year
of diagnosing cataracts.
The incidence
of Parkinson's disease
by the end of 2011
and the association
of Parkinson's disease
with cataracts
and other comorbidities
were measured.
Results
The overall incidence
of Parkinson's disease
was 1.48-fold higher
in the cataract group
than the non-cataract group
(3.18 vs. 2.15
per 1000 person-years,
crude HR 1.48,
95% CI 1.32, 1.66).
After adjusting
for confounding factors,
the adjusted HR
of Parkinson's disease
was 1.26 (95% CI 1.12, 1.42)
for the cataract group,
when compared
with the non-cataract group.
Dementia
(HR 2.72, 95% CI 1.92, 3.84),
depression
(HR 2.09, 95% CI 1.63, 2.66),
hypertension
(HR 1.42, 95% CI 1.26, 1.61),
cerebrovascular disease
(HR 1.32, 95% CI 1.07, 1.63)
and age
(every one year,
HR 1.08, 95% CI 1.07, 1.09)
were other factors
significantly
related to Parkinson's disease.
Conclusions
Overall,
this study discloses
a 26% increased hazard
of Parkinson's disease
in cataract patients.
Further studies are required
to investigate
whether cataracts are
one of
non-motor manifestations
of Parkinson's disease.
Discussionを引用します。
of Parkinson's disease.
Discussionを引用します。
This means
that cataracts are
potentially associated
with the risk
of Parkinson's disease.
Although
the mechanisms
behind the association
between cataracts
and Parkinson's disease
cannot be determined
in this observational study,
the available literature
reveals that
cataracts
and Parkinson's disease
could be linked
by mitochondrial
dysfunction theory.
Mitochondria
are highly
important
intracellular organelles
with numerous
key cellular functions,
particularly involved in
the regulation
of energy metabolism,
calcium homeostasis,
stress response
and even apoptosis.
Theoretically,
mitochondrial
genetic mutations
cause alteration
of mitochondrial activities,
including
depletion
of energy production,
inhibition of
the electron transport chain,
reactive oxygen species,
as well as
subsequent oxidative stress,
which can result in
oxidation
of cellular components,
loss of cellular function,
cellular damage
and even apoptosis
of lens and neurons.
Therefore,
mitochondrial dysfunction
, at least partially,
could contribute to
the pathogenesis of
cataracts
and Parkinson's disease.