復習。
・Trophozoites in blood smear are characteristic for malaria.
マラリアは末血で。
・ Oocysts in stool with an acid fast stain are a classical finding of cryptosporidium induced diarrhea.
クリプトスポリジウムは便染色。
・HUS is most commonly associated with infection with Shigella dysentariae and Escherichia coli O157:H7-- both express shiga-toxin.
Composed of two components, A and B.
The B component binds to the cell membrane and allows entry of the A toxin. This component inactivates ribosomes, thereby stopping protein synthesis, which leads to cell death.
HUSは赤痢と大腸菌O-157.
腎不全、微小血管の溶血性貧血、DIC、発熱を引き起こす。
トキシンAがリボソームを無効化→タンパク合成阻害→細胞死の流れ。
・HUSの特徴は血小板減少、腎不全、溶血性貧血
Clinical features of HUS include:
・thrombocytopenia
・microangiopathic hemolytic anemia
・acute renal failure
The toxin produced by Bordetella pertussis (B. pertussis) over-activates adenylate cyclase by disabling the G-inhibitory protein.
百日咳菌の毒素はアデニル酸シクラーゼを活性化。
The toxin produced by Corynebacterium diphtheriae (C. diphtheriae) inactivates elongation factor (EF)-2 by adenosine diphosphate ribosylation.
ジフテリア菌はEF-2の不活性化。
ジフテリア菌：グラム陽性桿菌・放線菌、潜伏期間1-10日。発症するのは10％。
発症後数週間後に心筋炎の可能性あり。
・Schistosoma mansoni cercariae are commonly found in fresh waters in tropical and subtropical areas of sub-Saharan Africa, the Middle East, South America, and the Caribbean.
Treatment) praziquantel.
治療はプラジカンテル。
