全2回、コレステロールのことを書いてましたが。
糖尿病の人は新型コロナ肺炎リスクが高いのは高血糖で免疫が落ちるから感染しやすいと言われているのですが、今日FBでみたハーバードのシンクレア教授（ライフ スパンの著者）のツイートでは。研究室が閉鎖されたので、新型コロナの論文を解析中。で、このウィルスと糖化ヘモグロビン高が肺炎を重症化させるらしい。詳しいことは私には理解できないのですが。原文は以下
Treatments that seem to work are chloroquine (a cheap malarial drug), Gilliad's remdesivir with interferon-beta (in clinical trials from COV-19), plasma from recovered patients, and a steroid (methylprednisilone). Doctors in US are now using remdesivir off-label...
SARS-CoV2 attacks pneumocytes in lung, intestine, heart & cells lining blood vessels. In lung, CoV2 prevents cells from making biological detergents to keep lung passages open. Acute respiratory distress follows. O2 levels fall..but there's may be a dangerous underlying process..
..new work out of China yesterday says COVID-19 might also involve abnormal blood production. CoV genes 1 & 8 are predicted to interfere with heme, the red compound in blood, by kicking out the iron. Would explain why chloroquine seems effective as a treatment #CoronaVirusUpdate
Chloroquine is predicted to prevent orf1ab, ORF3a and ORF10 from attacking heme (red in red blood cells) and inhibit the binding of ORF8 to heme. Although 99% of the virus is seemingly stable, what's disturbing is ORF 1 and 8 are mutating the fastest...
..Positions nt28144 in ORF 8 and nt8782 in ORF1 are evolving. Samples out of China show they'd mutated 30.53% (29/95) and 29.47% (28/95), respectively. I'm currently figuring out why these are the ones mutating and how that would change the situation...
It may explain why diabetics and elderly are more susceptible. Blood sugar levels usually increase as we get older, increasing the amount of glycated hemoglobin (HbA1c) (I've tweeted about this before). The authors suggest these people would be more susceptible to because...
...the virus could more easily disrupt the heme in red blood cells. If so, the virus is very smart: it destroys the lung so patients can't take up oxygen AND reduces the body's ability to carry oxygen. (For this & other reasons, you should eat healthily the next 2 years)...
These ideas are testable. COVID-19 should correlate with HbA1c levels (seems true). Patients should have abnormalities in heme/porphyrin & they might have higher levels of free iron in tissues & blood. I will update with more info as it comes in. Stay safe. Below are links...
上記の健康的な食事とは当然高血糖にならない食事のこと、我が家は将来の心血管イベントを心配するより今は今後2年間（2年も！）HbA1cはなるべく低く保つことを第一目標にして行きます。
現在５．４％だから服薬量、ダイエットは現状維持で大丈夫と思うけど、今後は食後にソファでくつろぎすぎるのはご法度ですぜ。今までは食後に運動するのは消化管に負担をかけるからと避けていたけれど、散歩程度の軽い運動位は勧めることにします。