参考文献
 

1)小田倉弘典著 もう怖くない!心房細動の抗凝固療法 文光堂

2)Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation. Analysis of pooled data from five randomized controlled trials. Arch Intern Med 1994 Jul 11;154(13):1449-57.

3)2020年改訂版 不整脈薬物治療ガイドライン

4)Stuart J. Connolly, John Eikelboom, Campbell Joyner, et al. Apixaban in Patients with Atrial Fibrillation. N Engl J Med 2011; 364:806-817

5)Robert P. Giugliano, Christian T. Ruff, Eugene Braunwald, et al. Edoxaban versus Warfarin in Patients with Atrial Fibrillation. N Engl J Med 2013; 369:2093-2104

6)Manesh R. Patel, Kenneth W. Mahaffey, Jyotsna Garg, et al. Rivaroxaban versus Warfarin in Nonvalvular Atrial Fibrillation. N Engl J Med 2011; 365:883-891

7)Stuart J. Connolly, Michael D. Ezekowitz, Salim Yusuf, et al. Dabigatran versus Warfarin in Patients with Atrial Fibrillation.

8Ken Okumura, Masaharu Akao, Tetsuro Yoshida, et al. Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation. N Engl J Med 2020; 383:1735-1745

10)Angel Lanas, Francis K L Chan Peptic ulcer disease. Lancet 2017 Aug 5;390(10094):613-624.

11)S Hernández-Díaz, L A Rodríguez Association between nonsteroidal anti-inflammatory drugs and upper gastrointestinal tract bleeding/perforation: an overview of epidemiologic studies published in the 1990s. Arch Intern Med 2000 Jul 24;160(14):2093-9

12)Jia Qing Huang, Subbaramiah Sridhar, Richard H Hunt Role of Helicobacter pylori infection and non-steroidal anti-inflammatory drugs in peptic-ulcer disease: a meta-analysis. Lancet 2002 Jan 5;359(9300):14-22

13)T A Rockall, R F Logan, H B Devlin, T C Northfield. Incidence of and mortality from acute upper gastrointestinal haemorrhage in the United Kingdom. Steering Committee and members of the National Audit of Acute Upper Gastrointestinal Haemorrhage. BMJ 1995 Jul 22;311(6999):222-6

14)Laura E Targownik, Alice Nabalamba. Trends in management and outcomes of acute nonvariceal upper gastrointestinal bleeding: 1993-2003. Clin Gastroenterol Hepatol 2006 Dec;4(12):1459-1466.

15Sigrun Halvorsen, et al. Efficacy and safety of apixaban compared with warfarin according to age for stroke prevention in atrial fibrillation: observations from the ARISTOTLE trial. European Heart Journal 2014;35: 1864–1872

16)http://hospi.sakura.ne.jp/wp/wp-content/themes/generalist/img/medical/jhn-cq-tanba-201014.pdf

17)Paul Moayyedi, John W Eikelboom, Jackie Bosch, et al. Safety of Proton Pump Inhibitors Based on a Large, Multi-Year, Randomized Trial of Patients Receiving Rivaroxaban or Aspirin. Gastroenterology. 2019 Sep;157(3):682-691

18)Tze-Fan Chao, Chia-Jen Liu, Yenn-Jiang Lin et al. Oral Anticoagulation in Very Elderly Patients With Atrial Fibrillation: A Nationwide Cohort Study. Circulation 2018 Jul 3;138(1):37-47.

19)Eitaro Kodani,Hirotsugu Atarashi,Hiroshi Inoue, Use of Warfarin in Elderly Patients With Non-Valvular Atrial Fibrillation – Subanalysis of the J-RHYTHM Registry – Circulation Journal 2015 Volume 79 Issue 11 Pages 2345-2352.