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&quotThose who choose to increase their knowledge still further by reading ... will discover an exciting new world. &quot NOEL WHITTAKER, in &quotMaking Money Made Simple&quot 1989. The development of calcium antagonists has recently been described as representing &quotone of the major advances in cardiovascular thera173 peutics of the latter half of the twentieth century&quot (Braunwald, 1990). However, although the development of these drugs started in the mid173 nineteen sixties it is only recently that their real potential has begun to be appreciated. Even now the calcium antagonist saga is not complete, since new compounds continue to appear and new therapeutic applica173 tions emerge. Based on the experience gained in the clinics in which these drugs have been used recognition is being given now to the need to improve upon the prototypes of the group. Such improvement is resulting in the development and production not only of long-acting formulations of the prototypes 
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