Oligonucleotide Analysis

Oligonucleotides are a class of short-chain nucleic acids composed of deoxyribonucleotides or ribonucleotides. They can form base pairs with DNA, mRNA, or pre-mRNA through the principle of complementary base pairing. By precisely "silencing" certain genes, oligonucleotides can inhibit the expression of many proteins, thereby achieving the goal of curing diseases. This oligonucleotide array analysis, oligonucleotide microarray analysis, oligonucleotide hybridization analysis and oligonucleotide hplc analysis process is fundamental for elucidating genetic information, understanding gene expression patterns, and developing novel therapeutic strategies in areas such as genomics, genetics, and drug discovery.

INOMIXO Oligonucleotide Analysis by Mass Spectrometry

INOMIXO can provide quality research and quality control for oligonucleotide drugs such as ASOs and siRNAs, with CMA-ISO9001 quality certification, and a quality system that meets the requirements of NMPA and FDA.

Quality Attribute	Analytes	Attribute
Characterization	Reference batch of DS	MW/ Sequence/ Tm/Total content/Absorbance coefficient
Identification	Release batch of DS	MW/ Tm/ MS-MS sequencing
	Release batch of DP	MW
Assay	Release batch of DS and DP	Total content/Purity or assay
Purity and impurity profile	Release batch of DS and DP	Chromatographic purity (IC-RP)
		Chromatographic purity (IP-RP)
		Chromatographic purity (HILIC)
		CE purity
Impurities	Release batch of DS	Residual solvents/ Heavy metal residues/ Process-related impurities
Counterion testing	Release batch of DS
Water content	Release batch of DS
Safety	Release batch of DS and DP	Endotoxin
		Bioburden

Please note that the table provided only includes part of test items. For more detailed information on each project, please download the support documents or contact info@inomixo.com.

If you want to know more about oligonucleotide analytical methods, please visit our website.

More details of introduction to omics ppt, please visit our website.