Dynamiker Fungus 1 3 BD Glucan Assay
It's used for pan-fungal detection. (1-3)-β-D-glucan is the major cell wall component of most fungi such as Candida, Aspergillus in blood, Fusarium, etc. By spectrophotometric quantitative detection of (1-3)-β-D-glucan in human sample, this assay provides a diagnostic reference for invasive fungal diseases.
Specification
|
Catalogue |
DNK-1401-1 |
|
Method |
Colorimetric |
|
Specification |
96 tests |
|
Sample |
Serum |
|
Storage |
2-8℃ |
Principle
The pre-treated sera are added to the main reagent containing Factor G. Factor G is activated by (1-3)-β-D-glucan and the activated Factor G converts the proclotting enzyme to the clotting enzyme.
The clotting enzyme hydrolyses the substrate(Boc-leu-Gly-Arg-PNA) to release PNA.
The absorbance is measured kinetically at 405 nm.
The concentration of (1-3)-B-D-glucan is interpreted from a standard curve.
Adaptation Platform
The BDG Assay is working on a microplate reader with kinetic reading at 405nm and temperature control at 37C.
Recommended microplate readers are Tecan Sunrise or BioTek ELX808iu, with incubator and kinetic reading at 405nm.
Clinical Performance
White PL, et al: An evaluation of the performance of the Dynamiker®Fungus (1-3)-B-D-Glucan Assay to assist in the diagnosis of invasive aspergillosis, invasive candidiasis and Pneumocystis pneumonia. Med Mycol. 2017 Nov 1;55(8) : 843-850
Shabaan AE, et al: Role of serum 1,303-d-glucan assay in early diagnosis of invasive fungal infections in a neonatal intensive care unit. J Pediatr (Rio J). 2017.
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Dynamiker biotechnology was founded in 2014 as a specialist in the diagnosis of invasive fungal diseases. It is dedicated to the R&D, production and global sales of innovative in vitro diagnostic products for invasive fungal disease (IFD) and other pathogenic microorganisms. Dynamiker actively cooperates with GAFFI to promote the establishment of international reference laboratories and industry standards, participates in industry-university research and international project cooperation, and has a strategic cooperation with Pfizer China to jointly promote the accurate use of clinical antifungal drugs.
