Pentosan polysulfate sodium (PPS)
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HOW THIS MEDICATION IS USED
Pentosan polysulfate sodium can be used in acute Feline Lower Urinary Tract Disease, to facilitate the resolution of the episode. It is more commonly recommended as an on-going therapy to prevent future episodes. The jury is still out as to whether or not it is effective for this use. It is not effective in curtailing an active episode of lower urinary tract disease that is in progress. It is typically dosed twice daily which can be problematic for long term use especially in cats.
Most glycosaminoglycan supplements in veterinary medicine are used to treat degenerative arthritis, especially in dogs. This medication may also be used to assist the body in rebuilding damaged joint cartilage as cartilage is also made of glycosaminoglycans. This medication also has anti-inflammatory properties which could be further beneficial to an arthritis patient.
SIDE EFFECTS
Pentosan polysulfate sodium is similar in structure to the anti-coagulant heparin and, in fact, has 1/15th the anticoagulant strength of heparin. Pentosan polysulfate sodium should not be used in patients with known blood clotting disorders or with those with surgery planned in the near future.
INTERACTIONS WITH OTHER DRUGS
Pentosan polysulfate sodium should not be used with other medications that interfere with blood clotting.
CONCERNS AND CAUTIONS
Pentosan polysulfate sodium is metabolized through the liver. Patients with liver failure will not be as efficient at removing this compound from their bodies and dosage adjustment will likely be needed.
Mar Vista Animal Medical Centerより抜粋
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PPS is a polysulfate ester of xylan, a polymer prepared semisynthetically from beechwood plant material. PPS is chemically and structurally similar to heparin and glycosaminoglycan. The compound is approved by the FDA for use as an oral capsule for the treatment of interstitial cystitis in humans. An injectable product is available for use in humans, dogs, and horses in Australia and other countries. The mechanism of action is unknown. PPS stimulates hyaluronic acid and GAG synthesis in damaged joints, inhibits proteolytic enzymes including metalloproteinases, and scavenges free radicals. PPS may also decrease cytokine activity. In canine models of osteoarthritis, IM administration of PPS significantly decreased overall cartilage damage. Because PPS has a heparin-like structure, coagulopathies may be observed.
The Merck Veterinary Manual より抜粋
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clinical testing of pentosan polysulfate sodium in dog
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