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In the very early stages, there is a reduction cheap timberlands in hippocampal volume of 10 to 12 percent, which goes up to 20 to 30 percent in mild Alzheimer's disease, and 30 to 40 percent in later stages.In normal brains the rate of hippocampal shrinking is between 0.24 to 1.73 percent per year. In people with Alzheimer's disease it is between 2.2 andcheap michael kors purses 5.9 percent, notes the book "European Radiology."The reduction in hippocampal volume is due to both complete cell loss and cell damage. The damage is principally to regions at the end of a neuron, or synapses, which house mechanisms for signaling between neurons.Stephen Scheff and colleagues michael kors handbags cheap showed in the May 2007 edition of "Neurology" that even people with mild Alzheimer's disease had 55 percent fewer synapses in the CA1 region compared to normal controls.

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