After years of exploration,resistanting RNA (si RNA) by small molecule , it has achieved epigenetic resistance against exogenous nucleotides (Epigenetic inheritance of resistance) , which is explained and constructed in animal models . This "Inheritance of acquired characteristics." biology point has become a hot research topic in recent years.
Researchers recently found by a group of specific& small RNAs that represent hunger effect can transfer to the next generation, indicating that genetic biology is more complex than previously thought. U.S. NIH biologist Eugene Koonin introduced this situation , pointed that this performance proves silencing gene (induced starvation mode)caused by endogenous si RNA , which can transfer to the next generation through epigenetic, leading to growth of the third-generation descendants of life.
Koonin believes that the study results and recent prokaryotes (Department of Medical Journal paper --SCI translation polish) some results together indicate acquired Lamarckian theory of evolution is a major phenomenon. The researchers found that the nematode hunger specific generate a set of small RNAs. These RNAs persist for at least three generations, even nematodes were fed a normal diet. The researchers also found that these small RNAs targeting the nutritional intake of some genes play a role.
Researchers believe that this is because these small RNA can enter the germ cells (sperm or egg cell), when the nematodes in the replication of small RNA is independent of the DNA, and may be in the germ cells of the cell body is passed from one generation to the next. Epigenetic modifications without changing the DNA sequence in the case of controlling gene expression, including chromatin remodeling, histone modification, DNA methylation and microRNA pathway. Nutrition and other environmental factors that can affect cell metabolism, and therefore metabolism and epigenetic association between the increasingly attracted everyone's attention.
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