First, the side effects of metamizole drugs
In the antipyretic family, metamizole has the most effective fever, however the most adverse reactions are also dangerous. The merits of metamizole cannot be denied. Metamizole is a combo of aminopyrine and sodium sulfite. It was used as an antipyretic analgesic in the twenties. However, since the eighties, it is basically no extended used clinically. Metazizzole has been banned in 35 countries across the world, not to mention the Combined States, Japan, Australia, and even poor countries such as Nepal and Nigeria. However, the effect of our country is that metamizole is still in production, small clinics and pharmacies are still selling, and dangerous negative reaction cases occur frequently.
metamizole
Metamizole side outcomes
Some people have metamizole in their homes. It is not scientific to take them with head aches and fever. Metamizole is mainly used for antipyretic fever during high fever. It can be used for headache, pain, dysmenorrhea, and so forth., but it is generally not used because the first choice. Only in the case of acute high fever, severe illness, and no other effective antipyretic drugs are available. Could be used for crisis heat removal.
Metamizole has been available for years, and the efficacy of headaches for fever is very obvious. There are many people in non-urban areas. The long-term use of metamizole is very opposed. As it happens that long lasting use of metamizole can lead to a decline in granulocytes in the individual blood. In severe instances, granulocytosis can occur, demonstrating symptoms of fatigue and general malaise. If metamizole eats more, it will cause dependence. Be careful with metamizole.
Because metamizole has its own side effects, such as allergies, collapse, leukopenia, renal dysfunction, etc., serious can cause drug-induced aplastic low blood count, acute hematopoietic stagnation. In this article, if there are symptoms such as fever and headache, it is best not to take metamizole easily. You can use other antipyretic and analgesic drugs instead. When necessary, it is a good idea to come to the medical center in time.
Second, metamizole and which drugs will appear
1. The risk of bleeding when the drug is along with acenocoumarol, anthraquinone, dicoumarin, benzodiazepine, warfarin, eptifibatide, danaparone, low molecular weight heparin increase.
2. When combined with calcium supplement channel blockers, the danger of gastrointestinal bleeding boosts.
3. When combined with alendronate, the stimulating impact on the gastrointestinal tract is increased, so extreme caution should be exercised when used together.
4. Once the drug is combined with ketorolac, the gastrointestinal side effects increase, and there may be digestive ulcers, gastrointestinal bleeding and/or perforation.
5. This medicine can raise the risk of cyclosporine poisoning. When used collectively, renal dysfunction, cholestasis, and paresthesia may occur.
six. This drug can reduce the clearance rate of methotrexate, ultimately causing methotrexate poisoning, leukopenia, thrombocytopenia, anemia, poisonous renal damage, mucosal ulcer formation and other undesirable reactions.
7. When used in blend with lithium, the clearance rate of lithium is lowered, and the plasma concentration is increased, which may cause symptoms of lithium poisoning.
8. Once the drug is put together with ofloxacin and levofloxacin, it can inhibit the action of gamma-aminobutyric acidity, thereby increasing the chance of seizures.
9. Phentermine can interfere with the production of prostaglandins, so that the angiotensin-converting chemical inhibitor, β-adrenergic blocker antihypertensive effect and natriuretic effect are reduced.
10. Whenever along with loop diuretics and thiazide diuretics, the diuretic and antihypertensive effects of diuretics are reduced.
eleven. When along with potassium-sparing diuretics, the latter's diuretic effect is reduced, hyperkalemia may occur, and toxic kidney damage could also occur.
twelve. When used in combo with sulfonylureas, the metabolism of sulfonylureas is inhibited and the risk of hypoglycemia increases.
Third, the impact of taking metamizole
Despite the fact that the drug is less irritating to the stomach tract, it can cause various adverse reactions as follows:
1. Hematology: can cause neutropenia, the incidence rate is about 1. 1%, showing acute onset, and severe cases are deadly. Additionally, it may cause immune hemolytic anemia, thrombocytopenic purpura and aplastic anemia.
2. Pores and skin: It may cause allergic indications such as urticaria, drug eruption, and exudative erythema. In severe cases, exfoliative dermatitis and bullous epidermolysis can happen, and even dying can occur.
3. Local side effects: redness and pain may occur at the shot site, and it will subside after a day or two. High-dose intramuscular injection can cause severe large-scale aseptic necrosis in the injections, leading to toxemia and even death.
4. In some cases, anaphylactic shock may occur after administration of the drug, and even death may result.
5. In the case of intramuscular injection, some patients could have sweating, chest rigidity, and sudden drop in blood pressure, leading to collapse.
6. Acupoint injections can cause muscle atrophy, joint dysfunction and so on.
7. metamizole can also cause drowsiness, termes conseillés, headache, nausea, vomiting, dry out mouth, urinary discoloration, bronchospasm, pemphigus vulgaris and other adverse reactions.