Cardiac macrophages in maintaining heart homeostasis and regulating ventricular remodeling of heart diseases
M Kang, H Jia, M Feng, H Ren, J Gao, Y Liu, L Zhang… - Frontiers in Immunology, 2024
Macrophages are most important immune cell population in the heart. Cardiac
macrophages have broad-spectrum and heterogeneity, with two extreme polarization
phenotypes: M1 pro-inflammatory macrophages (CCR2-ly6Chi) and M2 anti-
inflammatory macrophages (CCR2-ly6Clo). Cardiac macrophages can reshape their
polarization states or phenotypes to adapt to their surrounding microenvironment by
altering metabolic reprogramming. The phenotypes and polarization states of cardiac …
macrophages have broad-spectrum and heterogeneity, with two extreme polarization
phenotypes: M1 pro-inflammatory macrophages (CCR2-ly6Chi) and M2 anti-
inflammatory macrophages (CCR2-ly6Clo). Cardiac macrophages can reshape their
polarization states or phenotypes to adapt to their surrounding microenvironment by
altering metabolic reprogramming. The phenotypes and polarization states of cardiac …
| • | 引用: SARS-CoV-2 spike protein mutation at cysteine-488 impairs its …  |
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[HTML] Tumor óseo de células gigantes, tratamiento y diagnóstico: revisión de la literatura
RA Delgado, GR Saldívar - Orthotips AMOT, 2024
El tumor de células gigantes (TCG) tiene una variedad muy versátil, desde la
presentación clínica en género y grupo etario hasta su grado de malignidad,
llegando a ser mortal. Es oportuna la clasificación radiográfica para definir el
pronóstico; determinar el diagnóstico histopatológico hoy en día es el gold standard.
El tratamiento médico consta de anticuerpos monoclonales para pacientes
inoperables, o en grado de metástasis, que actúan contra del receptor del ligando …
presentación clínica en género y grupo etario hasta su grado de malignidad,
llegando a ser mortal. Es oportuna la clasificación radiográfica para definir el
pronóstico; determinar el diagnóstico histopatológico hoy en día es el gold standard.
El tratamiento médico consta de anticuerpos monoclonales para pacientes
inoperables, o en grado de metástasis, que actúan contra del receptor del ligando …
| • | 引用: Isocitrate dehydrogenase mutation is frequently observed in giant … |
Activation Dynamics for the Taste Receptor as an Energy Sensor
K Sanematsu, N Shigemura - Current Oral Health Reports, 2024
Abstract Purpose of Review Sweet-taste receptors play a crucial role in maintaining
biological homeostasis by acting as energy sensors. However, the dynamics of this
receptor after binding remain unknown because previous studies have primarily
examined the static binding of the sweet taste receptor in complex with ligands. This
review focuses on the mechanisms underlying the allostery-mediated activation and
inactivation of the transmembrane domain of the sweet taste receptor subunit …
biological homeostasis by acting as energy sensors. However, the dynamics of this
receptor after binding remain unknown because previous studies have primarily
examined the static binding of the sweet taste receptor in complex with ligands. This
review focuses on the mechanisms underlying the allostery-mediated activation and
inactivation of the transmembrane domain of the sweet taste receptor subunit …
| • | 引用: Structural basis for perception of diverse chemical substances by … |
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