Glycosylation: mechanisms, biological functions and clinical implications
M He, X Zhou, X Wang - Signal Transduction and Targeted Therapy, 2024
Protein post-translational modification (PTM) is a covalent process that occurs in
proteins during or after translation through the addition or removal of one or more
functional groups, and has a profound effect on protein function. Glycosylation is one
of the most common PTMs, in which polysaccharides are transferred to specific
amino acid residues in proteins by glycosyltransferases. A growing body of evidence
suggests that glycosylation is essential for the unfolding of various functional …
proteins during or after translation through the addition or removal of one or more
functional groups, and has a profound effect on protein function. Glycosylation is one
of the most common PTMs, in which polysaccharides are transferred to specific
amino acid residues in proteins by glycosyltransferases. A growing body of evidence
suggests that glycosylation is essential for the unfolding of various functional …
| • | 引用: Focused differential glycan analysis with the platform antibody …  |
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Integrated diagnosis of glioma based on magnetic resonance images with incomplete ground truth labels
S Cao, Z Hu, X Xie, Y Wang, J Yu, B Yang, Z Shi, G Wu - Computers in Biology and …, 2024
Background Since the 2016 WHO guidelines, glioma diagnosis has entered an era
of integrated diagnosis, combining tissue pathology and molecular pathology. The
WHO has focused on promoting the application of molecular diagnosis in the
classification of central nervous system tumors. Genetic information such as IDH1
and 1p/19q are important molecular markers, and pathological grading is also a key
clinical indicator. However, obtaining genetic pathology labels is more costly than …
of integrated diagnosis, combining tissue pathology and molecular pathology. The
WHO has focused on promoting the application of molecular diagnosis in the
classification of central nervous system tumors. Genetic information such as IDH1
and 1p/19q are important molecular markers, and pathological grading is also a key
clinical indicator. However, obtaining genetic pathology labels is more costly than …
| • | 引用: Detection of IDH1 mutation in human gliomas: comparison of … |
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Podoplanin and its multifaceted roles in mammalian developmental program
YY Cheok, GMY Tan, YT Chan, S Abdullah, CY Looi… - Cells & Development, 2024
Podoplanin is a vital molecule which plays an integral part in the regulation of
development, immunity, and cancer. Expression of Podoplanin is detected at
different early developmental stages of mammalian embryo, and it functions to
modulate morphogenesis of various organ systems. In experimental animal models
of different genetic backgrounds, absence of Podoplanin results in either embryonic
lethality or immediate death upon birth, suggesting the importance of the gene in …
development, immunity, and cancer. Expression of Podoplanin is detected at
different early developmental stages of mammalian embryo, and it functions to
modulate morphogenesis of various organ systems. In experimental animal models
of different genetic backgrounds, absence of Podoplanin results in either embryonic
lethality or immediate death upon birth, suggesting the importance of the gene in …
| • | 引用: The expression of podoplanin and classic cadherins in the mouse … |
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[HTML] Clinical research progress of telomerase targeted cancer immunotherapy: a literature review
Y Wang, X Zhang, G Chen, M Shao - Translational Cancer Research, 2024
Methods: We investigated the research progress of telomerase immunotherapy in the
last 20 years from four electronic databases. Key Content and Findings: Telomerase-
targeted immunotherapies have been developed with the arising of a new era in
immuno-oncology, including peptide vaccines, DNA vaccines, dendritic cells (DCs),
adoptive cell transfer (ACT) therapies, antibodies, etc. Some of them have been
approved for undergoing clinical trials by the Food and Drug Administration (FDA) for …
last 20 years from four electronic databases. Key Content and Findings: Telomerase-
targeted immunotherapies have been developed with the arising of a new era in
immuno-oncology, including peptide vaccines, DNA vaccines, dendritic cells (DCs),
adoptive cell transfer (ACT) therapies, antibodies, etc. Some of them have been
approved for undergoing clinical trials by the Food and Drug Administration (FDA) for …
| • | 引用: Elucidation of the TMab-6 monoclonal antibody epitope against … |