Recent advances and applications of deep learning, electroencephalography, and modern analysis techniques in screening, evaluation, and mechanistic analysis of …
L Su, H Ji, J Kong, W Yan, Q Zhang, J Li, M Zuo - Trends in Food Science & …, 2024
Background Taste peptides are oligopeptides that improve the flavor and palatability
of food. Due to their unique taste characteristics and nutritional values, the
development of taste peptides has become a hot spot for food flavoring research and
commercial applications. Screening and evaluating of taste peptides based on
traditional experimental methods is inefficient and labor-intensive. Deep learning
and electroencephalogram can enable high-throughput screening of taste peptides …
of food. Due to their unique taste characteristics and nutritional values, the
development of taste peptides has become a hot spot for food flavoring research and
commercial applications. Screening and evaluating of taste peptides based on
traditional experimental methods is inefficient and labor-intensive. Deep learning
and electroencephalogram can enable high-throughput screening of taste peptides …
| • | 引用: Structural basis for perception of diverse chemical substances by |
Computational identification and experimental validation of potential inhibitors of JAK1 kinase from natural source for the effective treatment of colorectal …
PS Ramalingam, G Italiya, S Elangovan, RAK Mishra… - South African Journal of …, 2024
Colorectal cancer (CRC) has become a global threat worldwide with constantly
increasing incidence and mortality rates every year, especially in the US and China.
Janus kinase (JAK) is an intracellular non-receptor tyrosine that mediates the signal
transducer and activator of transcription (STAT) which orchestrates cytokine
signalling, oncogene expression, and modulation of transcription factors. Targeting
JAK holds promise as a therapeutic strategy for CRC. This present study focused on …
increasing incidence and mortality rates every year, especially in the US and China.
Janus kinase (JAK) is an intracellular non-receptor tyrosine that mediates the signal
transducer and activator of transcription (STAT) which orchestrates cytokine
signalling, oncogene expression, and modulation of transcription factors. Targeting
JAK holds promise as a therapeutic strategy for CRC. This present study focused on …
| • | 引用: Current targeted therapy for metastatic colorectal cancer  |
[HTML] Development and validation of a prognostic immunoinflammatory index for patients with gastric cancer
ZC Ba, XQ Zhu, ZG Li, YZ Li - World Journal of Gastroenterology, 2024
BACKGROUND Studies have demonstrated the influence of immunity and
inflammation on the development of tumors. Although single biomarkers of immunity
and inflammation have been shown to be clinically predictive, the use of biomarkers
integrating both to predict prognosis in patients with gastric cancer remains to be
investigated. AIM To investigate the prognostic and clinical significance of
inflammatory biomarkers and lymphocytes in patients undergoing surgical treatment …
inflammation on the development of tumors. Although single biomarkers of immunity
and inflammation have been shown to be clinically predictive, the use of biomarkers
integrating both to predict prognosis in patients with gastric cancer remains to be
investigated. AIM To investigate the prognostic and clinical significance of
inflammatory biomarkers and lymphocytes in patients undergoing surgical treatment …
| • | 引用: Roles of podoplanin in malignant progression of tumor |
[HTML] Phosphorylated telomerase reverse transcriptase contributes to the progression of papillary thyroid carcinoma
K Shio, Y Yamaya, E Suzuki, T Sato, Y Matsumoto… - Thyroid Science, 2024
Somatic mutations in the promoter region of telomerase reverse transcriptase (TERT)
occur at a high frequency in several cancer types and are associated with
malignancy potential and prognosis. Protein levels of TERT and phosphorylated
TERT (p-TERT) are related to malignancy potential. To explore the association of
TERT phosphorylation and malignancy or prognosis of thyroid cancer, we analyzed
the expression of p-TERT and the clinical features of papillary thyroid carcinoma …
occur at a high frequency in several cancer types and are associated with
malignancy potential and prognosis. Protein levels of TERT and phosphorylated
TERT (p-TERT) are related to malignancy potential. To explore the association of
TERT phosphorylation and malignancy or prognosis of thyroid cancer, we analyzed
the expression of p-TERT and the clinical features of papillary thyroid carcinoma …
| • | 10 件目の引用Phosphorylation of hTERT at threonine 249 is a … |
Lack of inflammation or immune response in cyst tissue of patients with symptomatic non-hydrocephalic pineal cysts
CLV Quesada, SB Rao, R Torp, P Niehusmann… - Journal of the Neurological …, 2024
Pineal cysts are frequently encountered as incidental findings in magnetic resonance
imaging, usually devoid of symptoms, yet some patients exhibit symptomatic
manifestations possibly associated with the cyst, even in the absence of
hydrocephalus. The etiology of these symptoms remains contentious. This study
aims to investigate the presence of lymphatic endothelial cell (LEC) markers and
indications of inflammation or immune response within the pineal cysts of patients …
imaging, usually devoid of symptoms, yet some patients exhibit symptomatic
manifestations possibly associated with the cyst, even in the absence of
hydrocephalus. The etiology of these symptoms remains contentious. This study
aims to investigate the presence of lymphatic endothelial cell (LEC) markers and
indications of inflammation or immune response within the pineal cysts of patients …
| • | 引用: Molecular analysis of the pathophysiological binding of the platelet … |
Effect of Biopolymers and Functionalized by Them Vaterite Microparticles on Platelet Aggregation
DV Grigorieva, EV Mikhalchik, NG Balabushevich… - Journal of Evolutionary …, 2024
Vaterite microparticles, metastable form of calcium carbonate, are promising forms of
delivery of medicinal compounds. For more efficient delivery of target molecules
(increased incorporation and retention), vaterite microparticles must be
functionalized with biopolymers. In this article the effect of polysaccharides, mucin
and vaterite microparticles, as well as hybrid vaterite microparticles with the above-
mentioned biopolymers was studied on platelet aggregation. It was found that …
delivery of medicinal compounds. For more efficient delivery of target molecules
(increased incorporation and retention), vaterite microparticles must be
functionalized with biopolymers. In this article the effect of polysaccharides, mucin
and vaterite microparticles, as well as hybrid vaterite microparticles with the above-
mentioned biopolymers was studied on platelet aggregation. It was found that …
| • | 引用: Molecular analysis of the pathophysiological binding of the platelet … |
Immune checkpoint regulation is critically involved in canine cutaneous histiocytoma regression
B Diehl, F Hansmann - Frontiers in Veterinary Science, 2024
Introduction Canine cutaneous histiocytoma (CCH) is a benign tumor frequently
occurring in young dogs which is derived from Langerhans cells (LC). Distinguishing
features of this tumor are its spontaneous regression following a rapid tumor growth.
Impaired control of immune checkpoints during tumor development and progression
is a widespread phenomenon which may result in an absent or ineffective immune
response. The interaction between the inflammatory response and the expression of …
occurring in young dogs which is derived from Langerhans cells (LC). Distinguishing
features of this tumor are its spontaneous regression following a rapid tumor growth.
Impaired control of immune checkpoints during tumor development and progression
is a widespread phenomenon which may result in an absent or ineffective immune
response. The interaction between the inflammatory response and the expression of …
| • | 引用: PD-L1 immunohistochemistry for canine cancers and clinical … |
[PDF] Intraoperative rapid molecular diagnosis aids glioma subtyping and guides precise surgical resection
J Li, Z Han, C Ma, H Chi, D Jia, K Zhang, Z Feng, B Han… - Annals of Clinical and …, 2024
Objective The molecular era of glioma diagnosis and treatment has arrived, and a
single rapid histopathology is no longer sufficient for surgery. This study sought to
present an automatic integrated gene detection system (AIGS), which enables rapid
intraoperative detection of IDH/TERTp mutations. Methods A total of 78 patients with
gliomas were included in this study. IDH/TERTp mutations were detected
intraoperatively using AIGS in 41 of these patients, and they were guided to surgical …
single rapid histopathology is no longer sufficient for surgery. This study sought to
present an automatic integrated gene detection system (AIGS), which enables rapid
intraoperative detection of IDH/TERTp mutations. Methods A total of 78 patients with
gliomas were included in this study. IDH/TERTp mutations were detected
intraoperatively using AIGS in 41 of these patients, and they were guided to surgical …
| • | 引用: A novel all-in-one intraoperative genotyping system for IDH1 … |
[PDF] Induction of Invasive Basal Phenotype in Triple-Negative Breast Cancers by Long Noncoding RNA BORG
F Niazi, KA Parker, SJ Mason, S Singh, WP Schiemann… - 2024
Long noncoding RNAs (lncRNAs) are known to play key roles in breast cancers;
however, detailed mechanistic studies of lncRNA function have not been conducted
in large cohorts of breast cancer tumors, nor have inter-donor and inter-subtype
variabilities been taken into consideration. Here we provide the first identification and
annotation of the human BORG lncRNA gene. Using multiple tumor cohorts of
human breast cancers, we show that while BORG expression is strongly induced in …
however, detailed mechanistic studies of lncRNA function have not been conducted
in large cohorts of breast cancer tumors, nor have inter-donor and inter-subtype
variabilities been taken into consideration. Here we provide the first identification and
annotation of the human BORG lncRNA gene. Using multiple tumor cohorts of
human breast cancers, we show that while BORG expression is strongly induced in …
| • | 引用: The role of MMP-1 in breast cancer growth and metastasis to the …  |