HIF-1α activation impairs dendrites formation and elongation in osteocytogenesis
X Li, J Zhao, L Chen, X Zhou, M Qiu, L Deng, K Yang… - Heliyon, 2024
Osteocytes are terminally differentiated cells derived from osteoblasts and are deeply
embedded within the bone matrix. They play a critical role in bone remodeling by
generating a lacuno-canalicular network (LCN) and controlling the transport of
nutrients. Due to the absence of blood vessels within the bone matrix, it is widely
believed that osteocytes develop in a hypoxic environment. However, the
mechanisms of osteocytogenesis and the role of oxygen sensing in this process …
embedded within the bone matrix. They play a critical role in bone remodeling by
generating a lacuno-canalicular network (LCN) and controlling the transport of
nutrients. Due to the absence of blood vessels within the bone matrix, it is widely
believed that osteocytes develop in a hypoxic environment. However, the
mechanisms of osteocytogenesis and the role of oxygen sensing in this process …
| • | 引用: Roles of podoplanin in malignant progression of tumor  |
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[PDF] CROSSTALK BETWEEN PLATELETS AND CANCER CELLS: Do cancer cells interact with transfused platelets?
T Hueneburg - 2024
In Australia, oncology patients receive up to 60% of platelet transfusions. Interactions
between platelets and cancer cells in oncology patients are well documented,
notably, crosstalk between the C-type like lectin receptor on platelets and podoplanin
(PDPN) on malignant cells. Described here is the first in-vitro investigation of
crosstalk between stored apheresis platelets and cancer cells. Platelets were stored
for 7 days at 20-24° C with constant agitation. During storage, samples were taken …
between platelets and cancer cells in oncology patients are well documented,
notably, crosstalk between the C-type like lectin receptor on platelets and podoplanin
(PDPN) on malignant cells. Described here is the first in-vitro investigation of
crosstalk between stored apheresis platelets and cancer cells. Platelets were stored
for 7 days at 20-24° C with constant agitation. During storage, samples were taken …
| • | 引用: Roles of podoplanin in malignant progression of tumor |
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[HTML] Establishment of Canine Oral Mucosal Melanoma Cell Lines and Their Xenogeneic Animal Models
S Li, Z Liu, J Lv, D Lv, H Xu, H Shi, G Liu, D Lin, Y Jin - Cells, 2024
Canine oral melanoma is the most prevalent malignant tumor in dogs and has a poor
prognosis due to its high aggressiveness and high metastasis and recurrence rates.
More research is needed into its treatment and to understand its pathogenic factors.
In this study, we isolated a canine oral mucosal melanoma (COMM) cell line
designated as COMM6605, which has now been stably passaged for more than 100
generations, with a successful monoclonal assay and a cell multiplication time of …
prognosis due to its high aggressiveness and high metastasis and recurrence rates.
More research is needed into its treatment and to understand its pathogenic factors.
In this study, we isolated a canine oral mucosal melanoma (COMM) cell line
designated as COMM6605, which has now been stably passaged for more than 100
generations, with a successful monoclonal assay and a cell multiplication time of …
| • | 引用: PD-L1 immunohistochemistry for canine cancers and clinical … |
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Engineering photodynamics for treatment, priming and imaging
G Obaid, JP Celli, M Broekgaarden, AL Bulin… - Nature Reviews …, 2024
Photodynamic therapy (PDT) is a photochemistry-based treatment approach that
relies on the activation of photosensitizers by light to locally generate reactive
oxygen species that induce cellular cytotoxicity, in particular for the treatment of
tumours. The cytotoxic effects of PDT are depth-limited owing to light penetration
limits in tissue. However, photodynamic priming (PDP), which inherently occurs
during PDT, can prime the tissue microenvironment to adjuvant therapies beyond the …
relies on the activation of photosensitizers by light to locally generate reactive
oxygen species that induce cellular cytotoxicity, in particular for the treatment of
tumours. The cytotoxic effects of PDT are depth-limited owing to light penetration
limits in tissue. However, photodynamic priming (PDP), which inherently occurs
during PDT, can prime the tissue microenvironment to adjuvant therapies beyond the …
| • | 引用: Targeted phototherapy for malignant pleural mesothelioma: near … |
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Integrated virtual screening coupled with sensory evaluation identifies N-succinyl-L-tryptophan as a novel compound with multiple taste enhancement properties
P Huang, Z Wang, Y Cheng, W Gao, C Cui - Food Chemistry, 2024
N-Succinyl amino acids (N-Suc-AAs) are garnering attention for their potential as
taste-active compounds. The intricate variety of N-Suc-AAs presented considerable
challenges in identifying those with taste-active properties. Consequently, we
employed structure-based virtual screening to pinpoint taste-active N-Suc-AAs,
revealing N-succinyl-L-tryptophan (ST) as a compound with high affinity for different
taste receptors. Following this discovery, ST was synthesized through an enzymatic …
taste-active compounds. The intricate variety of N-Suc-AAs presented considerable
challenges in identifying those with taste-active properties. Consequently, we
employed structure-based virtual screening to pinpoint taste-active N-Suc-AAs,
revealing N-succinyl-L-tryptophan (ST) as a compound with high affinity for different
taste receptors. Following this discovery, ST was synthesized through an enzymatic …
| • | 引用: Structural basis for perception of diverse chemical substances by … |