Ectodomain shedding of PLA2R1 is mediated by the metalloproteases ADAM10 and ADAM17
G Dolla, S Nicolas, LR dos Santos, A Bourgeois… - Journal of Biological Chemistry
ABSTRACT Phospholipase A2 receptor 1 (PLA2R1) is a 180-kDa transmembrane
protein that plays a role in inflammation and cancer, and is the major autoantigen in
membranous nephropathy (MN), a rare but severe autoimmune kidney disease. A
soluble form of PLA2R1 has been detected in mouse and human serum. It is likely
produced by proteolytic shedding of membrane-bound PLA2R1 but the mechanism
is unknown. Here, we show that human PLA2R1 is cleaved by A Disintegrin And …
protein that plays a role in inflammation and cancer, and is the major autoantigen in
membranous nephropathy (MN), a rare but severe autoimmune kidney disease. A
soluble form of PLA2R1 has been detected in mouse and human serum. It is likely
produced by proteolytic shedding of membrane-bound PLA2R1 but the mechanism
is unknown. Here, we show that human PLA2R1 is cleaved by A Disintegrin And …
| • | 引用: Mechanistic insights into ectodomain shedding: susceptibility of …  |
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[PDF] Untargeted Metabolomics im Tumorgewebe von IDH1-mutierten versus IDH1-Wildtyp diffusen Gliomen ZNS WHO Grad 2-4
B Bayer - 2024
Die Entdeckung der IDH1-Mutation und weiterer molekularer Marker hat zu neuen
diagnostischen Kriterien geführt. Die metabolische Funktion der IDH1-Mutation und
die Entdeckung des Onkometaboliten 2-HG bei IDH-mutierten Gliomen hat zudem
die Bedeutung metabolischer Veränderungen und deren mögliche diagnostische
und therapeutische Implikationen durch Darstellung in der MRS und den Einsatz
neuer Inhibitoren von IDH1, zB Ivosidenib, aufgezeigt. Da die …
diagnostischen Kriterien geführt. Die metabolische Funktion der IDH1-Mutation und
die Entdeckung des Onkometaboliten 2-HG bei IDH-mutierten Gliomen hat zudem
die Bedeutung metabolischer Veränderungen und deren mögliche diagnostische
und therapeutische Implikationen durch Darstellung in der MRS und den Einsatz
neuer Inhibitoren von IDH1, zB Ivosidenib, aufgezeigt. Da die …
| • | 引用: Quantitative metabolome analysis profiles activation of … |
IMT030122, A novel engineered EpCAM/CD3/4-1BB tri-specific antibody, enhances T-cell recruitment and demonstrates anti-tumor activity in mouse models of …
J Shen, N Qian, G Xu, X Dou, Y An, C Yang, Y Liu… - International …, 2024
Colorectal cancer is a major global health burden, with limited efficacy of traditional
treatment modalities in improving survival rates. However, recently advances in
immunotherapy has improved treatment outcomes for patients with this cancer. To
address the continuing need for improved treatment efficacy, this study introduced a
novel tri-specific antibody, IMT030122, that targets EpCAM, 4-1BB, and CD3. We
evaluated the pharmacological efficacy and mechanism of action of IMT030122 in …
treatment modalities in improving survival rates. However, recently advances in
immunotherapy has improved treatment outcomes for patients with this cancer. To
address the continuing need for improved treatment efficacy, this study introduced a
novel tri-specific antibody, IMT030122, that targets EpCAM, 4-1BB, and CD3. We
evaluated the pharmacological efficacy and mechanism of action of IMT030122 in …
| • | 引用: Development of a novel anti-EpCAM monoclonal antibody for … |
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[HTML] Therapeutic Apheresis Using a β2-Microglobulin Removal Column Reduces Circulating Tumor Cell Count
Y Komura, S Kimura, A Takaura, Y Hirasawa… - Journal of Personalized …, 2024
Background: Open Access Communication Therapeutic Apheresis Using a β2-
Microglobulin Removal Column Reduces Circulating Tumor Cell Count by Yasuo
Komura 1, Shintarou Kimura 2, Ayana Takaura 1, Yumi Hirasawa 2, Katsunori
Segawa 1, Hiromi Muranishi 1, Osamu Imataki 3, Yoshihisa Kumayama 4 and
Koichiro Homma 5,* 1 Rinku Medical Clinic, 2F Medical Rinku Port, 3-41 Rinku
Ouraiminami, Osaka 598-0047, Japan
Microglobulin Removal Column Reduces Circulating Tumor Cell Count by Yasuo
Komura 1, Shintarou Kimura 2, Ayana Takaura 1, Yumi Hirasawa 2, Katsunori
Segawa 1, Hiromi Muranishi 1, Osamu Imataki 3, Yoshihisa Kumayama 4 and
Koichiro Homma 5,* 1 Rinku Medical Clinic, 2F Medical Rinku Port, 3-41 Rinku
Ouraiminami, Osaka 598-0047, Japan
| • | 引用: Roles of podoplanin in malignant progression of tumor  |