Neurological complications of platelet disorders and disorders of coagulation
S Baghshomali, FE Gomez, A Tadevosyan, MA Kumar - Oxford Textbook of …, 2024
Neurological sequelae of coagulation factor deficiencies, inherited and acquired
thrombophilias, and cancer-related thrombosis are routinely encountered in
hospitalized patients. The most feared complications of these states are life-
threatening brain haemorrhages and catastrophic ischaemic events that cause
permanent disability or death. Treatment of these cerebrovascular injuries are
remarkably time-sensitive and the window of opportunity to intervene and to …
thrombophilias, and cancer-related thrombosis are routinely encountered in
hospitalized patients. The most feared complications of these states are life-
threatening brain haemorrhages and catastrophic ischaemic events that cause
permanent disability or death. Treatment of these cerebrovascular injuries are
remarkably time-sensitive and the window of opportunity to intervene and to …
| • | 引用: Involvement of the snake toxin receptor CLEC-2, in podoplanin … |
An unexpected role for the ketogenic diet in triggering tumor metastasis by modulating BACH1-mediated transcription
Z Su, Y Liu, Z Xia, AK Rustgi, W Gu - Science Advances, 2024
We have found that the ketogenic (Keto) diet is able to, unexpectedly, promote the
metastatic potential of cancer cells in complementary mouse models. Notably, the
Keto diet–induced tumor metastasis is dependent on BTB domain and CNC homolog
1 (BACH1) and its up-regulation of pro-metastatic targets, including cell migration–
inducing hyaluronidase 1, in response to the Keto diet. By contrast, upon genetic
knockout or pharmacological inhibition of endogenous BACH1, the Keto diet …
metastatic potential of cancer cells in complementary mouse models. Notably, the
Keto diet–induced tumor metastasis is dependent on BTB domain and CNC homolog
1 (BACH1) and its up-regulation of pro-metastatic targets, including cell migration–
inducing hyaluronidase 1, in response to the Keto diet. By contrast, upon genetic
knockout or pharmacological inhibition of endogenous BACH1, the Keto diet …
| • | 引用: BACH1 promotes pancreatic cancer metastasis by repressing … |
Rupatadine inhibits colorectal cancer cell proliferation through the PIP5K1A/Akt/CDK2 pathway
L Jiang, Z Zhang, Z Luo, L Li, S Yuan, M Cui, K He… - Biomedicine & …, 2024
Abstract Background Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
(PIP5K1A) acts upstream of the Akt regulatory pathway and is abnormally expressed
in many types of malignancies. However, the role and mechanism of PIP5K1A in
colorectal cancer (CRC) have not yet been reported. In this study, we aimed to
determine the association between PIP5K1A and progression of CRC and assess
the efficacy and mechanism by which rupatadine targets PIP5K1A. Methods Firstly …
(PIP5K1A) acts upstream of the Akt regulatory pathway and is abnormally expressed
in many types of malignancies. However, the role and mechanism of PIP5K1A in
colorectal cancer (CRC) have not yet been reported. In this study, we aimed to
determine the association between PIP5K1A and progression of CRC and assess
the efficacy and mechanism by which rupatadine targets PIP5K1A. Methods Firstly …
| • | 引用: Current targeted therapy for metastatic colorectal cancer  |
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Development of a Sensitive Anti-Mouse CCR5 Monoclonal Antibody for Flow Cytometry
H Suzuki, T Tanaka, G Li, T Ouchida, MK Kaneko… - Monoclonal Antibodies in …, 2024
CC chemokine receptor 5 (CCR5), a member of the G protein-coupled receptor
family, is the most common coreceptor for the human immunodeficiency virus type 1.
CCR5 is also involved in the pathogenesis of tumors and inflammatory diseases. The
CCR5 antagonists including monoclonal antibodies (mAbs) have been developed
and evaluated in clinical trials. In this study, we developed novel mAbs for mouse
CCR5 (mCCR5) using the Cell-Based Immunization and Screening (CBIS) method …
family, is the most common coreceptor for the human immunodeficiency virus type 1.
CCR5 is also involved in the pathogenesis of tumors and inflammatory diseases. The
CCR5 antagonists including monoclonal antibodies (mAbs) have been developed
and evaluated in clinical trials. In this study, we developed novel mAbs for mouse
CCR5 (mCCR5) using the Cell-Based Immunization and Screening (CBIS) method …
| • | 引用: Epitope Mapping of Anti-Mouse CCR3 Monoclonal Antibodies … |
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[HTML] Exploring the Potentiality of a Plant Platform for Monoclonal Antibody Production in Veterinary Medicine
B Morel, C Favrot, L Mirande, C Grünwald-Gruber… - Vaccines, 2024
Canine atopic dermatitis (CAD) is an allergic, inflammatory, and pruritic skin disease
associated with the production of IgE antibodies against environmental allergens
and mainly house dust mite allergens. This complex dermatological pathology
involves Interleukin 31 (IL-31) as a central itch mediator. One of the most effective
CAD treatments is a caninized monoclonal antibody (mAb) called Lokivetmab. It is
produced in CHO cells and targets specifically canine IL-31 (cIL-31) and blocks its …
associated with the production of IgE antibodies against environmental allergens
and mainly house dust mite allergens. This complex dermatological pathology
involves Interleukin 31 (IL-31) as a central itch mediator. One of the most effective
CAD treatments is a caninized monoclonal antibody (mAb) called Lokivetmab. It is
produced in CHO cells and targets specifically canine IL-31 (cIL-31) and blocks its …
| • | 引用: Generation of a canine anti-canine CD20 antibody for canine … |