Role of BACH1 in multiple myeloma
Y Chen, Z Zeng, J Chen - Hematology, 2024
ABSTRACT Objective Examine Bach1 protein expression in bone marrow biopsy
specimens obtained from newly diagnosed multiple myeloma (NDMM) and iron
deficiency anemia (IDA) patients. Conduct a thorough analysis to explore the
potential connection between Bach1 and the onset as well as treatment response of
NDMM. Methods This study investigated Bach1 expression in bone marrow biopsy
tissues from NDMM and IDA patients. Immunohistochemical staining and Image-pro …
specimens obtained from newly diagnosed multiple myeloma (NDMM) and iron
deficiency anemia (IDA) patients. Conduct a thorough analysis to explore the
potential connection between Bach1 and the onset as well as treatment response of
NDMM. Methods This study investigated Bach1 expression in bone marrow biopsy
tissues from NDMM and IDA patients. Immunohistochemical staining and Image-pro …
| • | 引用: BACH1 promotes pancreatic cancer metastasis by repressing …  |
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Modified superior bleb needling of rare hypertrophic bleb after trabeculectomy: A case series
L Gan, F Tang, J Liao, H Xiang, L Tang - European Journal of Ophthalmology, 2024
Background Hypertrophic bleb is a rare complication of glaucoma filtration surgery
characterized by an elevated bleb extended through the nasal 180 degrees of the
eye and usually with a normal IOP. Currently, there is little experience and no
existing standardized treatment. We describe a new method called modified superior
bleb needling and evaluate the clinical outcomes in affected eyes. Methods In this
retrospective, consecutive interventional case series, patients who developed …
characterized by an elevated bleb extended through the nasal 180 degrees of the
eye and usually with a normal IOP. Currently, there is little experience and no
existing standardized treatment. We describe a new method called modified superior
bleb needling and evaluate the clinical outcomes in affected eyes. Methods In this
retrospective, consecutive interventional case series, patients who developed …
| • | 引用: Functional, structural, and molecular identification of lymphatic Expand available targets for CAR-T therapy to overcome tumor drug resistance based on the" Evolutionary Traps"X Wang, P Wang, Y Liao, X Zhao, R Hou, S Li, Z Guan… - Pharmacological Research, 2024
Based on the concept of" Evolutionary Traps", targeting survival essential genes
obtained during tumor drug resistance can effectively eliminate resistant cells. While, it still faces limitations. In this study, lapatinib-resistant cells were used to test the concept of" Evolutionary Traps" and no suitable target stand out because of the identified genes without accessible drug. However, a membrane protein PDPN, which is low or non-expressed in normal tissues, is identified as highly expressed in …
Cancer progression and tumor hypercoagulability: a platelet perspectiveY Zhang, J Zeng, S Bao, B Zhang, X Li, H Wang… - Journal of Thrombosis and …, 2024
Venous thromboembolism, which is common in cancer patients and accompanies or even precedes malignant tumors, is known as cancer-related thrombosis and is an important cause of cancer-associated death. At present, the exact etiology of the elevated incidence of venous thrombosis in cancer patients remains elusive. Platelets play a crucial role in blood coagulation, which is intimately linked to the development of arterial thrombosis. Additionally, platelets contribute to tumor …  |