[HTML] Klotho is highly expressed in the chief sites of regulated potassium secretion, and it is stimulated by potassium intake
HJ Jung, TD Pham, XT Su, TV Grigore, JG Hoenderop… - Scientific Reports, 2024
Klotho regulates many pathways in the aging process, but it remains unclear how it is
physiologically regulated. Because Klotho is synthesized, cleaved, and released
from the kidney; activates the chief urinary K+ secretion channel (ROMK) and
stimulates urinary K+ secretion, we explored if Klotho protein is regulated by dietary
K+ and the potassium-regulatory hormone, Aldosterone. Klotho protein along the
nephron was evaluated in humans and in wild-type (WT) mice; and in mice lacking …
physiologically regulated. Because Klotho is synthesized, cleaved, and released
from the kidney; activates the chief urinary K+ secretion channel (ROMK) and
stimulates urinary K+ secretion, we explored if Klotho protein is regulated by dietary
K+ and the potassium-regulatory hormone, Aldosterone. Klotho protein along the
nephron was evaluated in humans and in wild-type (WT) mice; and in mice lacking …
| • | 引用: Establishment of the anti-Klotho monoclonal antibodies and Sinensetin protects against periodontitis through binding to Bach1 enhancing its ubiquitination degradation and improving oxidative stressZ Yuan, J Li, F Xiao, Y Wu, Z Zhang, J Shi, J Qian, X Wu… - International Journal of Oral …, 2024
Periodontitis is a chronic inflammatory and immune reactive disease induced by the
subgingival biofilm. The therapeutic effect for susceptible patients is often unsatisfactory due to excessive inflammatory response and oxidative stress. Sinensetin (Sin) is a nature polymethoxylated flavonoid with anti-inflammatory and antioxidant activities. Our study aimed to explore the beneficial effect of Sin on periodontitis and the specific molecular mechanisms. We found that Sin attenuated …
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