Understanding the immunosuppressive microenvironment of glioma: mechanistic insights and clinical perspectives
H Lin, C Liu, A Hu, D Zhang, H Yang, Y Mao - Journal of Hematology & Oncology, 2024
Glioblastoma (GBM), the predominant and primary malignant intracranial tumor,
poses a formidable challenge due to its immunosuppressive microenvironment,
thereby confounding conventional therapeutic interventions. Despite the established
treatment regimen comprising surgical intervention, radiotherapy, temozolomide
administration, and the exploration of emerging modalities such as immunotherapy
and integration of medicine and engineering technology therapy, the efficacy of …
poses a formidable challenge due to its immunosuppressive microenvironment,
thereby confounding conventional therapeutic interventions. Despite the established
treatment regimen comprising surgical intervention, radiotherapy, temozolomide
administration, and the exploration of emerging modalities such as immunotherapy
and integration of medicine and engineering technology therapy, the efficacy of …
| • | 引用: CAR T cells targeting podoplanin reduce orthotopic glioblastomas …  |
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[HTML] Advancements in precision nanomedicine design targeting the anoikis-platelet interface of circulating tumor cells
M Tang, Z Zhang, P Wang, F Zhao, L Miao, Y Wang… - Acta Pharmaceutica Sinica …, 2024
Tumor metastasis, the apex of cancer progression, poses a formidable challenge in
therapeutic endeavors. Circulating tumor cells (CTCs), resilient entities originating
from primary tumors or their metastases, significantly contribute to this process by
demonstrating remarkable adaptability. They survive shear stress, resist anoikis,
evade immune surveillance, and thwart chemotherapy. This comprehensive review
aims to elucidate the intricate landscape of CTC formation, metastatic mechanisms …
therapeutic endeavors. Circulating tumor cells (CTCs), resilient entities originating
from primary tumors or their metastases, significantly contribute to this process by
demonstrating remarkable adaptability. They survive shear stress, resist anoikis,
evade immune surveillance, and thwart chemotherapy. This comprehensive review
aims to elucidate the intricate landscape of CTC formation, metastatic mechanisms …
| • | 引用: Involvement of the snake toxin receptor CLEC-2, in podoplanin …Complications of XEN gel stent implantation for the treatment of glaucoma: a systematic reviewL Gan, L Wang, J Chen, L Tang - Frontiers in Medicine, 2024
Aim This study was aimed to summarize the complications and their management
associated with XEN gel stent implantation. Methods A systematic review of literature was conducted using Medline (via PubMed), EMBASE, the Cochrane Library databases, and China National Knowledge Infrastructure, from their inception to February 1, 2024. Results A total of 48 studies published between 2017 and 2024 were identified and included in the systematic review, including 16 original studies …
Triiodothyronine enhances various forms of kidney-specific klotho protein and suppresses the Wnt/β-catenin pathway: Insights from in-vitro, in-vivo and in-silico …SK Mohanty, AK Mohanty, MS Kumar, K Suchiang - Cellular Signalling, 2024
Age-related diseases are intricately linked to the molecular processes underlying
aging, with the decline of the antiaging protein Klotho being a key factor. Investigating these processes is crucial for developing therapeutic strategies. The age-associated reduction in Klotho expression, coupled with a decline in the endocrine hormone triiodothyronine (T3), prompted a detailed exploration of their potential interplay. Our research, conducted through both in-vitro and in-vivo studies …
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