Enhanced cellular therapy: revolutionizing adoptive cellular therapy
MY Xu, N Zeng, CQ Liu, JX Sun, Y An, SH Zhang… - Experimental Hematology & …, 2024
Enhanced cellular therapy has emerged as a novel concept following the basis of
cellular therapy. This treatment modality applied drugs or biotechnology to directly
enhance or genetically modify cells to enhance the efficacy of adoptive cellular
therapy (ACT). Drugs or biotechnology that enhance the killing ability of immune
cells include immune checkpoint inhibitors (ICIs)/antibody drugs, small molecule
inhibitors, immunomodulatory factors, proteolysis targeting chimera (PROTAC) …
cellular therapy. This treatment modality applied drugs or biotechnology to directly
enhance or genetically modify cells to enhance the efficacy of adoptive cellular
therapy (ACT). Drugs or biotechnology that enhance the killing ability of immune
cells include immune checkpoint inhibitors (ICIs)/antibody drugs, small molecule
inhibitors, immunomodulatory factors, proteolysis targeting chimera (PROTAC) …
| • | 引用: Efficacy of cancer-specific anti-podoplanin CAR-T cells and …  |
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[PDF] Plaque Protein Carbamylation Is Associated with Atherosclerosis Progression and Uremia and Accumulates in Foam Cells
V Saar-Kovrov, A Pawlowska, A Guillot, MJJ Gijbels… - Tackling the Complexity of …, 2024
Introduction α-Klotho (Klotho) is a type I transmembrane protein which is highly
conserved among human, mouse and rat (up to 94% homological sequence) 1 and
primarily expressed in the kidney, in both proximal and distal tubuli, though some
expression has been shown in choroid plexus, parathyroid gland and sinoatrial
node2. Membrane-bound Klotho plays an important role in a wide range of
physiological and pathophysiological processes, as recently reviewed in3. For …
conserved among human, mouse and rat (up to 94% homological sequence) 1 and
primarily expressed in the kidney, in both proximal and distal tubuli, though some
expression has been shown in choroid plexus, parathyroid gland and sinoatrial
node2. Membrane-bound Klotho plays an important role in a wide range of
physiological and pathophysiological processes, as recently reviewed in3. For …
| • | 引用: Establishment of the anti-Klotho monoclonal antibodies and … |
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Salwa Hareem, Vigneswar Reddy Ashireddygari
P Tammineni, RK Kancha - Biomedical Aspects of Solid Cancers
Epidemiology: Central nervous system (CNS) cancers affect a staggering percentage
of the population across all ages accounting to 1.6% of global incidence of all
cancers [1]. CNS cancer ranks tenth in terms of mortality [1]. Eastern Asia has the
highest cases and fatality rate, followed by South-Central Asia and Northern
America. According to GLOBOCAN, males show higher global incidence (168,346
cases; cumulative risk: 0.40) and mortality rates (138,277 deaths; cumulative risk …
of the population across all ages accounting to 1.6% of global incidence of all
cancers [1]. CNS cancer ranks tenth in terms of mortality [1]. Eastern Asia has the
highest cases and fatality rate, followed by South-Central Asia and Northern
America. According to GLOBOCAN, males show higher global incidence (168,346
cases; cumulative risk: 0.40) and mortality rates (138,277 deaths; cumulative risk …
| • | 引用: Characterizing invading glioma cells based on IDH1-R132H and |
MMPs-related risk model identification and SAA1 promotes clear cell renal cell carcinoma migration via ERK-AP1-MMPs axis
H Wei, Y Li, J Zhang, C Xu, D Wei, C Quan, S Zhu - Scientific Reports, 2024
Abstract Matrix Metalloproteinases (MMPs) have been demonstrated to be essential
in facilitating the migration and metastasis of clear cell renal cell carcinoma (ccRCC).
However, the ability of the MMP family to predict clinical outcomes and guide optimal
therapeutic strategies for ccRCC patients remains incompletely understood. In this
investigation, we initially conducted a thorough examination of the MMP family in pan-
cancer. Notably, MMPs exhibited distinctive significance in ccRCC. Following this …
in facilitating the migration and metastasis of clear cell renal cell carcinoma (ccRCC).
However, the ability of the MMP family to predict clinical outcomes and guide optimal
therapeutic strategies for ccRCC patients remains incompletely understood. In this
investigation, we initially conducted a thorough examination of the MMP family in pan-
cancer. Notably, MMPs exhibited distinctive significance in ccRCC. Following this …
| • | 引用: The role of MMP-1 in breast cancer growth and metastasis to the … |