Establishment of a novel microfluidic co-culture system for simultaneous analysis of multiple indicators of gefitinib sensitivity in colorectal cancer cells
X Li, W Li, J Wang, Q Wang, M Liang, S Chen, W Ba… - Microchimica Acta, 2024
The therapeutic effect of gefitinib on colorectal cancer (CRC) is unclear, but it has
been reported that stromal cells in the tumor microenvironment may have an impact
on drug sensitivity. Herein, we established a microfluidic co-culture system and
explored the sensitivity of CRC cells co-cultured with cancer-associated fibroblasts
(CAFs) to gefitinib. The system consisted of a multichannel chip and a Petri dish. The
chambers in the chip and dish were designed to continuously supply nutrients for …
been reported that stromal cells in the tumor microenvironment may have an impact
on drug sensitivity. Herein, we established a microfluidic co-culture system and
explored the sensitivity of CRC cells co-cultured with cancer-associated fibroblasts
(CAFs) to gefitinib. The system consisted of a multichannel chip and a Petri dish. The
chambers in the chip and dish were designed to continuously supply nutrients for …
| • | 引用: Current targeted therapy for metastatic colorectal cancer  |
 |
 |
 |
 |
Cancer cell metabolism and antitumour immunity
M De Martino, JC Rathmell, L Galluzzi… - Nature Reviews …, 2024
Accumulating evidence suggests that metabolic rewiring in malignant cells supports
tumour progression not only by providing cancer cells with increased proliferative
potential and an improved ability to adapt to adverse microenvironmental conditions
but also by favouring the evasion of natural and therapy-driven antitumour immune
responses. Here, we review cancer cell-intrinsic and cancer cell-extrinsic
mechanisms through which alterations of metabolism in malignant cells interfere with …
tumour progression not only by providing cancer cells with increased proliferative
potential and an improved ability to adapt to adverse microenvironmental conditions
but also by favouring the evasion of natural and therapy-driven antitumour immune
responses. Here, we review cancer cell-intrinsic and cancer cell-extrinsic
mechanisms through which alterations of metabolism in malignant cells interfere with …
| • | 引用: Upregulation of PD-L1 expression by prostaglandin E2 and the …  |