Enhancing Glioblastoma Immunotherapy with Integrated Chimeric Antigen Receptor T Cells through the Re-Education of Tumor-Associated Microglia and …
N Zhu, S Chen, Y Jin, M Wang, L Fang, L Xue, D Hua… - ACS Nano, 2024
Glioblastoma (GBM) is an aggressive brain cancer that is highly resistant to treatment
including chimeric antigen receptor (CAR)-T cells. Tumor-associated microglia and
macrophages (TAMs) are major contributors to the immunosuppressive GBM
microenvironment, which promotes tumor progression and treatment resistance.
Hence, the modulation of TAMs is a promising strategy for improving the
immunotherapeutic efficacy of CAR-T cells against GBM. Molecularly targeting drug …
including chimeric antigen receptor (CAR)-T cells. Tumor-associated microglia and
macrophages (TAMs) are major contributors to the immunosuppressive GBM
microenvironment, which promotes tumor progression and treatment resistance.
Hence, the modulation of TAMs is a promising strategy for improving the
immunotherapeutic efficacy of CAR-T cells against GBM. Molecularly targeting drug …
| • | 引用: Efficacy of cancer-specific anti-podoplanin CAR-T cells and …  |
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[HTML] Characterization of Plant Produced VHH Antibodies Against Cobra Venom Toxins for Antivenom Therapy
S Vitayathikornnasak, K Rattanapisit, A Malla… - Biotechnology Reports, 2024
Cobra (Naja kaouthia) venom contains many toxins including α-neurotoxin (αNTX)
and phospholipase A2 (PLA2), which can cause neurodegeneration, respiratory
failure, and even death. The traditional antivenom derived from animal serum faces
many challenges and limitations. Heavy-chain-only antibodies (HCAb), fusing V HH
with human IgG Fc region, offer advantages in tissue penetration, antigen binding,
and extended half-life. This research involved the construction and transient …
and phospholipase A2 (PLA2), which can cause neurodegeneration, respiratory
failure, and even death. The traditional antivenom derived from animal serum faces
many challenges and limitations. Heavy-chain-only antibodies (HCAb), fusing V HH
with human IgG Fc region, offer advantages in tissue penetration, antigen binding,
and extended half-life. This research involved the construction and transient …
| • | 引用: Prevention of necrosis caused by transient expression in Nicotiana … |
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Studies on Treatment Within the Scope of Medical Biotechnology for Pancreatic Diseases
D Aylar, A Karatug Kacar - Molecular Biotechnology, 2024
The pancreas is made of two compartments: the exocrine pancreas, a source of
digestive enzymes, and the endocrine islets which produce vital hormones. Distinct
diseases could arise in the pancreas such as diabetes, neuroendocrine tumors,
pancreatitis, and pancreatic cancers. Various treatment methods are being
researched against these diseases. Treatment with recombinant proteins,
therapeutic antibodies, vaccination, gene therapy, tissue engineering, and stem cell …
digestive enzymes, and the endocrine islets which produce vital hormones. Distinct
diseases could arise in the pancreas such as diabetes, neuroendocrine tumors,
pancreatitis, and pancreatic cancers. Various treatment methods are being
researched against these diseases. Treatment with recombinant proteins,
therapeutic antibodies, vaccination, gene therapy, tissue engineering, and stem cell …
| • | 引用: H2Mab-19 anti-human epidermal growth factor receptor 2 … |