Accelerated plasma-cell differentiation in Bach2-deficient mouse B cells is caused by altered IRF4 functions
K Ochiai, H Shima, T Tamahara, N Sugie, R Funayama… - The EMBO Journal, 2024
Transcription factors BACH2 and IRF4 are both essential for antibody class-switch
recombination (CSR) in activated B lymphocytes, while they oppositely regulate the
differentiation of plasma cells (PCs). Here, we investigated how BACH2 and IRF4
interact during CSR and plasma-cell differentiation. We found that BACH2 organizes
heterochromatin formation of target gene loci in mouse splenic B cells, including
targets of IRF4 activation such as Aicda, an inducer of CSR, and Prdm1, a master …
recombination (CSR) in activated B lymphocytes, while they oppositely regulate the
differentiation of plasma cells (PCs). Here, we investigated how BACH2 and IRF4
interact during CSR and plasma-cell differentiation. We found that BACH2 organizes
heterochromatin formation of target gene loci in mouse splenic B cells, including
targets of IRF4 activation such as Aicda, an inducer of CSR, and Prdm1, a master …
| • | 引用: The mTOR-Bach2 cascade controls cell cycle and class switch … |