RevCAR-expressing immune effector cells for targeting of Fn14-positive glioblastoma
HA Saleh, N Mitwasi, L R. Loureiro, A Kegler, KEG Soto… - Cancer Gene Therapy, 2024
In recent studies, we have established the unique adapter chimeric antigen receptor
(CAR) platform RevCAR which uses, as an extracellular CAR domain, a peptide
epitope instead of an antibody domain. RevCAR adapters (termed RevCAR target
modules, RevTMs) are bispecific antibodies that enable the reversible ON/OFF
switch of the RevCAR system, improving the safety compared to conventional CARs.
Here, we describe for the first time its use for retargeting of both T and NK-92 cells. In …
(CAR) platform RevCAR which uses, as an extracellular CAR domain, a peptide
epitope instead of an antibody domain. RevCAR adapters (termed RevCAR target
modules, RevTMs) are bispecific antibodies that enable the reversible ON/OFF
switch of the RevCAR system, improving the safety compared to conventional CARs.
Here, we describe for the first time its use for retargeting of both T and NK-92 cells. In …
| • | 引用: Efficacy of cancer-specific anti-podoplanin CAR-T cells and …  |
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[PDF] MONOCLONAL ANTIBODIES AGAINST CTLA-4 AND PD-L1 RECEPTORS OF THE CATTLE IMMUNE SYSTEM
SN Borovikov, LА Tokhtarova, KN Mukantayev… - HERALD OF SCIENCE OF …, 2024
With the progression of bovine leukemia virus (BLV), the concentration of T-cells, as
well as CTLA-4 and PD-1 receptors on their cytoplasmic membrane increases.
Elevated concentrations of regulatory T-cells lead to increased production of
transforming growth factor-β (TGF β), suppression of interferon-γ (IFN-γ) expression,
tumor necrosis factor-α (TNF-α), and inhibition of natural killer (NK) cells. Effector and
cytotoxic T-lymphocytes, as well as the production of cytokines IFN-γ and TNF-α, play …
well as CTLA-4 and PD-1 receptors on their cytoplasmic membrane increases.
Elevated concentrations of regulatory T-cells lead to increased production of
transforming growth factor-β (TGF β), suppression of interferon-γ (IFN-γ) expression,
tumor necrosis factor-α (TNF-α), and inhibition of natural killer (NK) cells. Effector and
cytotoxic T-lymphocytes, as well as the production of cytokines IFN-γ and TNF-α, play …
| • | 引用: Combined immune checkpoint blockade enhances antiviral … |
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Quantifying the Lymphatic Transport of Model Therapeutics from the Brain in Rats
TA Hoang, G Gracia, E Cao, JA Nicolazzo… - Molecular Pharmaceutics, 2024
In recent years, the drainage of fluids, immune cells, antigens, fluorescent tracers,
and other solutes from the brain has been demonstrated to occur along lymphatic
outflow pathways to the deep cervical lymph nodes in the neck. To the best of our
knowledge, no studies have evaluated the lymphatic transport of therapeutics from
the brain. The objective of this study was to determine the lymphatic transport of
model therapeutics of different molecular weights and lipophilicity from the brain …
and other solutes from the brain has been demonstrated to occur along lymphatic
outflow pathways to the deep cervical lymph nodes in the neck. To the best of our
knowledge, no studies have evaluated the lymphatic transport of therapeutics from
the brain. The objective of this study was to determine the lymphatic transport of
model therapeutics of different molecular weights and lipophilicity from the brain …
| • | 引用: Development and characterization of a novel Prox1-EGFP … |
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Recombinant expression and tryptophan-assisted analysis of human sweet taste receptor T1R3's extracellular domain in sweetener interaction studies
SB Jin, HA Kim, JA Shin, NH Jung, SY Park, S Hong… - Preparative Biochemistry & …, 2024
The human palate can discern multiple tastes; however, it predominantly perceives
five fundamental flavors: sweetness, saltiness, sourness, bitterness, and umami.
Sweetness is primarily mediated through the sweet taste receptor, a membrane-
bound heterodimeric structure comprising T1R2-T1R3. However, unraveling the
structural and mechanistic intricacies of the sweet taste receptor has proven
challenging. This study aimed to address this knowledge gap by expressing an …
five fundamental flavors: sweetness, saltiness, sourness, bitterness, and umami.
Sweetness is primarily mediated through the sweet taste receptor, a membrane-
bound heterodimeric structure comprising T1R2-T1R3. However, unraveling the
structural and mechanistic intricacies of the sweet taste receptor has proven
challenging. This study aimed to address this knowledge gap by expressing an …
| • | 引用: Structural basis for perception of diverse chemical substances by … |