LASSO Based Analysis for Prediction of Prognostic Signature Genes Associated with Breast Cancer
S Guha - bioRxiv, 2024
Background: Cancer is a genetic disease, where gene alterations play a significant
role in the disease onset and pathogenesis. Analysis of the underlying gene
interaction pathways could reveal new biomarkers and could also potentially help in
the development of targeted drugs for therapeutics. Microarray techniques have
emerged as powerful tools capable of simultaneously measuring the expression
levels of thousands of genes, making them invaluable in cancer biology research …
role in the disease onset and pathogenesis. Analysis of the underlying gene
interaction pathways could reveal new biomarkers and could also potentially help in
the development of targeted drugs for therapeutics. Microarray techniques have
emerged as powerful tools capable of simultaneously measuring the expression
levels of thousands of genes, making them invaluable in cancer biology research …
| • | 引用: Development of anti-mouse CC chemokine receptor 8 monoclonal …  |
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Recombinant monoclonal antibody production in yeasts: Challenges and considerations
PK Das, A Sahoo, VD Veeranki - International Journal of Biological Macromolecules, 2024
Monoclonal antibodies (mAbs) are laboratory-based engineered protein molecules
with a monovalent affinity or multivalent avidity towards a specific target or antigen,
which can mimic natural antibodies that are produced in the human immune systems
to fight against detrimental pathogens. The recombinant mAb is one of the most
effective classes of biopharmaceuticals produced in vitro by cloning and expressing
synthetic antibody genes in a suitable host. Yeast is one of the potential hosts among …
with a monovalent affinity or multivalent avidity towards a specific target or antigen,
which can mimic natural antibodies that are produced in the human immune systems
to fight against detrimental pathogens. The recombinant mAb is one of the most
effective classes of biopharmaceuticals produced in vitro by cloning and expressing
synthetic antibody genes in a suitable host. Yeast is one of the potential hosts among …
| • | 引用: Engineering of mucin-type human glycoproteins in yeast cells |
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Extracellular Vesicle Biomarkers for Thrombosis
B Li, T Luo, S Liu, H Feng, Q Wang, L Zheng - Extracellular Vesicles: From Bench to …, 2024
Extracellular vesicles (EVs) participate in thrombosis via the functions of molecule
expression on their surfaces, including tissue factor (TF) and phosphatidylserine
(PS). TF is an important protein involved in the beginning of the extrinsic pathway,
whereas PS contributes to the assembly of the prothrombinase complex by
supporting the negatively charged membrane. Additionally, some other EV-linked
molecules also participate in coagulation and have potential applications as …
expression on their surfaces, including tissue factor (TF) and phosphatidylserine
(PS). TF is an important protein involved in the beginning of the extrinsic pathway,
whereas PS contributes to the assembly of the prothrombinase complex by
supporting the negatively charged membrane. Additionally, some other EV-linked
molecules also participate in coagulation and have potential applications as …
| • | 引用: Involvement of the snake toxin receptor CLEC-2, in podoplanin … |
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Extracellular Vesicle Biomarkers for Diagnosis of Cardiovascular Diseases
L Peng, H Zhang - Extracellular Vesicles: From Bench to Bedside, 2024
Cardiovascular disease (CVD) is the leading cause of mortality worldwide. There is
an urgent need for early detection biomarkers, which will benefit patients in the early
stages of the disease, prior to the occurrence of obvious clinical symptoms.
Extracellular vesicles (EVs) carry specific parental cell-derived cargo that reflects
physiological and pathological features; thus, EVs may represent diagnostic
biomarkers. As key mediators of intercellular communication, EVs play active roles in …
an urgent need for early detection biomarkers, which will benefit patients in the early
stages of the disease, prior to the occurrence of obvious clinical symptoms.
Extracellular vesicles (EVs) carry specific parental cell-derived cargo that reflects
physiological and pathological features; thus, EVs may represent diagnostic
biomarkers. As key mediators of intercellular communication, EVs play active roles in …
| • | 引用: Involvement of the snake toxin receptor CLEC-2, in podoplanin … |
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[PDF] Investigate release of DOX drug in electrospun DOX@ SiO2/PVA nanofiber
RS Naseri, H Hamidinezhad, MR Sazegar, M Behjati - 2024
Electrospinning nanofibers (NFs) are an operational release system for drugs due to
the high specific surface area. In this study, doxorubicin hydrochloride (DOX) is
added to a mixture of tetraethyl orthosilicate (TEOS, Si (OC 2 H 5)), hydrochloric acid
(HCL), ethanol (C 2 H 5 OH), DOX, and distilled water during the formation of SiO 2
using the sol-gel approach. The obtained DOX@ SiO 2 nanoparticles are then added
into a 7%(wt) solution of polyvinyl alcohol (PVA) in water before electrospinning …
the high specific surface area. In this study, doxorubicin hydrochloride (DOX) is
added to a mixture of tetraethyl orthosilicate (TEOS, Si (OC 2 H 5)), hydrochloric acid
(HCL), ethanol (C 2 H 5 OH), DOX, and distilled water during the formation of SiO 2
using the sol-gel approach. The obtained DOX@ SiO 2 nanoparticles are then added
into a 7%(wt) solution of polyvinyl alcohol (PVA) in water before electrospinning …
| • | 引用: A canine chimeric monoclonal antibody targeting PD-L1 and its … |