Prospects and challenges of CAR-T cell therapy combined with ICIs
Y Lv, X Luo, Z Xie, J Qiu, J Yang, Y Deng, R Long… - Frontiers in Oncology, 2024
Immune checkpoint molecules are a group of molecules expressed on the surface of
immune cells that primarily regulate their immune homeostasis. Chimeric antigen
receptor (CAR) T cell therapy is an immunotherapeutic technology that realizes
tumor-targeted killing by constructing synthetic T cells expressing specific antigens
through biotechnology. Currently, CAR-T cell therapy has achieved good efficacy in
non-solid tumors, but its treatment of solid tumors has not yielded the desired results …
immune cells that primarily regulate their immune homeostasis. Chimeric antigen
receptor (CAR) T cell therapy is an immunotherapeutic technology that realizes
tumor-targeted killing by constructing synthetic T cells expressing specific antigens
through biotechnology. Currently, CAR-T cell therapy has achieved good efficacy in
non-solid tumors, but its treatment of solid tumors has not yielded the desired results …
| • | 引用: Efficacy of cancer-specific anti-podoplanin CAR-T cells and …  |
 |
 |
 |
 |
[PDF] Research progress of intestinal microbiota in targeted therapy and immunotherapy of colorectal cancer
X Zhou, Y Zhao, R Zhao, S Shafi, Y Yang, G Liu, SB Liu - 2024
Colorectal cancer (CRC) is one of the most common malignancies of the digestive
tract, with increasing morbidity and mortality worldwide, and is the third most
common malignancy in the world. At present, the main treatment methods for CRC
include surgery, chemotherapy, targeted therapy, and immunotherapy. Regulation of
the gut microbiota is one of the most promising new strategies for CRC treatment. Gut
microbiota interacts with host cells to regulate many physiological processes, such …
tract, with increasing morbidity and mortality worldwide, and is the third most
common malignancy in the world. At present, the main treatment methods for CRC
include surgery, chemotherapy, targeted therapy, and immunotherapy. Regulation of
the gut microbiota is one of the most promising new strategies for CRC treatment. Gut
microbiota interacts with host cells to regulate many physiological processes, such …
| • | 引用: Current targeted therapy for metastatic colorectal cancer |
|
|
|
|
[PDF] The role, relevance and management of immune exhaustion in bovine infectious diseases
S Sharma, N Kumar, BT Rouse, K Sharma… - Heliyon, 2024
Immune exhaustion is a state of immune cell dysfunction that occurs most commonly
following chronic exposure to an antigen which persists after the immune response
fails to remove it. Exhaustion has been studied most thoroughly with several cancers,
but has also been observed in several chronic infectious diseases. The topic has
mainly been studied with CD8+ T cells, but it can also occur with CD4+ T cells and
other immune cell types too. Exhaustion is characterized by a hierarchical loss of …
following chronic exposure to an antigen which persists after the immune response
fails to remove it. Exhaustion has been studied most thoroughly with several cancers,
but has also been observed in several chronic infectious diseases. The topic has
mainly been studied with CD8+ T cells, but it can also occur with CD4+ T cells and
other immune cell types too. Exhaustion is characterized by a hierarchical loss of …
| • | 引用: Upregulation of PD-L1 expression by prostaglandin E2 and the … |
|
|
|
|
A retrospective study of chemotherapeutic effect without wide-margin surgery or radiation therapy in dogs with oral malignant melanoma
Y Xia, AT Liao, J Lee - The Canadian Veterinary Journal, 2024
Background Effective treatment for canine oral malignant melanoma (eg, curative-
intent surgery) may not be feasible or radiation therapy may be unavailable.
However, chemotherapy is usually an option, and more information is needed
regarding its use without adequate local treatments. Objective Our objective was to
investigate the efficacy of chemotherapy in canine oral malignant melanoma without
adequate local control, using carboplatin with dose reduction in small-breed dogs …
intent surgery) may not be feasible or radiation therapy may be unavailable.
However, chemotherapy is usually an option, and more information is needed
regarding its use without adequate local treatments. Objective Our objective was to
investigate the efficacy of chemotherapy in canine oral malignant melanoma without
adequate local control, using carboplatin with dose reduction in small-breed dogs …
| • | 引用: PD-L1 immunohistochemistry for canine cancers and clinical … |
|
|
|
|
[HTML] Simultaneous Recording of Remote Domain Dynamics in Membrane Proteins Using the Double-Labeled DXB/DXT Technique
K Mio, T Ohkubo, D Sasaki, M Sugiura, K Kawaguchi… - Membranes, 2024
Protein dynamics play important roles in biological functions, which accompany
allosteric structure changes. Diffracted X-ray blinking (DXB) uses monochromatic X-
rays and nanocrystal probes. The intramolecular motion of target proteins is
analyzed from the intensity changes in detector signals at the diffraction rings. In
contrast, diffracted X-ray tracking (DXT) elucidates molecular dynamics by analyzing
the trajectories of Laue spots. In this study, we have developed a dual-labeling …
allosteric structure changes. Diffracted X-ray blinking (DXB) uses monochromatic X-
rays and nanocrystal probes. The intramolecular motion of target proteins is
analyzed from the intensity changes in detector signals at the diffraction rings. In
contrast, diffracted X-ray tracking (DXT) elucidates molecular dynamics by analyzing
the trajectories of Laue spots. In this study, we have developed a dual-labeling …
| • | 引用: PA tag: a versatile protein tagging system using a super high … |
|
|
|
|
[PDF] Single Nucleotide Polymorphisms of podoplanin and their role in the concurrent occurrence of preeclampsia and HIV in women of African descent
Z Mtshali, T Naicker - 2024
Research has consistently demonstrated alterations in podoplanin expression within
the placenta of women with preeclampsia. Notably, anomalous podoplanin
expression has been observed within the syncytiotrophoblast layer, hinting at a
possible involvement in the pathogenesis of the condition. This study aims to
examine the possible connection between specific variations in podoplanin
(rs1148455, rs10927904, and rs7518611) and susceptibility to preeclampsia …
the placenta of women with preeclampsia. Notably, anomalous podoplanin
expression has been observed within the syncytiotrophoblast layer, hinting at a
possible involvement in the pathogenesis of the condition. This study aims to
examine the possible connection between specific variations in podoplanin
(rs1148455, rs10927904, and rs7518611) and susceptibility to preeclampsia …
| • | 引用: Incorporation of podoplanin into HIV released from HEK-293T cells … |