Chemical range recognized by the ligand-binding domain in a representative amino acid-sensing taste receptor, T1r2a/T1r3, from medaka fish
H Ishida, N Yasui, A Yamashita - PloS one, 2024
Taste receptor type 1 (T1r) proteins are responsible for recognizing nutrient
chemicals in foods. In humans, T1r2/T1r3 and T1r1/T1r3 heterodimers serve as the
sweet and umami receptors that recognize sugars or amino acids and nucleotides,
respectively. T1rs are conserved among vertebrates, and T1r2a/T1r3 from medaka
fish is currently the only member for which the structure of the ligand-binding domain
(LBD) has been solved. T1r2a/T1r3 is an amino acid receptor that recognizes various …
chemicals in foods. In humans, T1r2/T1r3 and T1r1/T1r3 heterodimers serve as the
sweet and umami receptors that recognize sugars or amino acids and nucleotides,
respectively. T1rs are conserved among vertebrates, and T1r2a/T1r3 from medaka
fish is currently the only member for which the structure of the ligand-binding domain
(LBD) has been solved. T1r2a/T1r3 is an amino acid receptor that recognizes various …
| • | 引用: Structural basis for perception of diverse chemical substances by …  |
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Matrix Metalloproteinase 1 Acts as an Independent Prognostic Biomarker Correlated with Immune Infiltration in Breast Cancer
Y Li, W Li, S Wang, J Chen, L Deng, D Li, Y Zhong… - Journal of Biomedical …, 2024
Matrix metalloproteinase 1 (MMP1) is overexpressed in multiple human tumors.
However, the role of MMP1 in breast cancer (BRCA) has not been explored. The
relationship between MMP1 expression and immune cell infiltration was conducted
using Tumor Immune Estimation Resource (TIMER, https://cistrome. shinyapps.
io/timer/), and the survival curve was plotted using Kaplan-Meier with log-rank test.
The influence of MMP1 on immune infiltration, Gene Ontology and Kyoto …
However, the role of MMP1 in breast cancer (BRCA) has not been explored. The
relationship between MMP1 expression and immune cell infiltration was conducted
using Tumor Immune Estimation Resource (TIMER, https://cistrome. shinyapps.
io/timer/), and the survival curve was plotted using Kaplan-Meier with log-rank test.
The influence of MMP1 on immune infiltration, Gene Ontology and Kyoto …
| • | 引用: The role of MMP-1 in breast cancer growth and metastasis to the Endothelial CLEC-1b plays a protective role against cancer hematogenous metastasisE Yamazaki, K Ikeda, R Urata, D Ueno, A Katayama… - … and Biophysical Research …, 2024
Metastasis, which is the spread of cancer cells into distant organs, is a critical
determinant of prognosis in patients with cancer, and blood vessels are the major route for cancer cells to spread systemically. Extravasation is a critical process for the hematogenous metastasis; however, its underlying molecular mechanisms remain poorly understood. Here, we identified that senescent ECs highly express C-type lectin domain family 1 member B (CLEC-1b), and that endothelial CLEC-1b inhibits …
[PDF] STING is significantly increased in high-grade glioma with high risk of recurrenceM Zhong, M Long, C Han, S Ji, Q Yang - OncoImmunology, 2024
In this study, we aimed to comprehensively characterize the potential relationships
among the frequently mutated genes, well-known homologous recombination repair (HRR) proteins, and immune proteins in glioma from a clinical perspective. A total of 126 surgical tissues from patients initially diagnosed with glioma were included. The genetic alterations were tested using the targeted next-generation sequencing technique. The expression of HRR proteins, immune proteins, and genetic alteration …
Check for updates Chapter 18J Ullrich, L Haueis, C Ohlhoff, A Zemella, S Kubick - Recombinant Glycoproteins: Methods …
Although membrane proteins are abundant in nature, their investigation is limited
due to bottlenecks in heterologous overexpression and consequently restricted accessibility for downstream applications. In this chapter, we address these challenges by presenting a fast and straightforward synthesis platform based on eukaryotic cell-free protein synthesis (CFPS) and an efficient solubilization strategy using styrene-maleic acid (SMA) copolymers. We demonstrate CFPS of TWIK-1, a …
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