A prognostic nomogram integrating carcinoembryonic antigen levels for predicting overall survival in elderly patients with stage II–III colorectal cancer
H Zhang, R Wang, T Yu, D Yu, C Song, B Ma, J Li - Journal of Gastrointestinal …, 2024
Background: With the aging of the population, colorectal surgeons will have to face
more elderly colorectal cancer (CRC) patients in the future. We aim to analyze
independent risk factors affecting overall survival in elderly (age≥ 65 years) patients
with stage II–III CRC and construct a nomogram to predict patient survival. Methods:
A total of 3,016 elderly CRC patients with stage II–III were obtained from the SEER
database. Univariate Cox regression and the least absolute shrinkage and selection …
more elderly colorectal cancer (CRC) patients in the future. We aim to analyze
independent risk factors affecting overall survival in elderly (age≥ 65 years) patients
with stage II–III CRC and construct a nomogram to predict patient survival. Methods:
A total of 3,016 elderly CRC patients with stage II–III were obtained from the SEER
database. Univariate Cox regression and the least absolute shrinkage and selection …
| • | 引用: Current targeted therapy for metastatic colorectal cancer  |
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[HTML] B cell memory: from generation to reactivation: a multipronged defense wall against pathogens
MZ Syeda, T Hong, C Huang, W Huang, Q Mu - Cell Death Discovery, 2024
Abstract Development of B cell memory is a conundrum that scientists are still
exploring. Studies have been conducted in vitro and using advanced animal models
to elucidate the mechanism underlying the generation of memory B cells (MBCs), the
precise roles of MBCs against pathogens, and their protective functions against
repeated infections throughout life. Lifelong immunity against invading diseases is
mainly the result of overcoming a single infection. This protection is largely mediated …
exploring. Studies have been conducted in vitro and using advanced animal models
to elucidate the mechanism underlying the generation of memory B cells (MBCs), the
precise roles of MBCs against pathogens, and their protective functions against
repeated infections throughout life. Lifelong immunity against invading diseases is
mainly the result of overcoming a single infection. This protection is largely mediated …
| • | 引用: The mTOR-Bach2 cascade controls cell cycle and class switch  |