FOXO3/Rab7-Mediated Lipophagy and Its Role in Zn-Induced Lipid Metabolism in Yellow Catfish (Pelteobagrus fulvidraco)
F Xiao, C Chen, W Zhang, J Wang, K Wu - Genes, 2024
Lipophagy is a selective autophagy that regulates lipid metabolism and reduces
hepatic lipid deposition. However, the underlying mechanism has not been
understood in fish. In this study, we used micronutrient zinc (Zn) as a regulator of
autophagy and lipid metabolism and found that Ras-related protein 7 (rab7) was
involved in Zn-induced lipophagy in hepatocytes of yellow catfish Pelteobagrus
pelteobagrus. We then characterized the rab7 promoter and identified binding sites …
hepatic lipid deposition. However, the underlying mechanism has not been
understood in fish. In this study, we used micronutrient zinc (Zn) as a regulator of
autophagy and lipid metabolism and found that Ras-related protein 7 (rab7) was
involved in Zn-induced lipophagy in hepatocytes of yellow catfish Pelteobagrus
pelteobagrus. We then characterized the rab7 promoter and identified binding sites …
| • | 引用: SARS-CoV-2 Spike Protein Mutation at Cysteine-488 Impairs Its …  |
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The Molecular Theory of Sweet Taste: Revisit, Update, and Beyond: Miniperspective
H Zheng, X Xu, Y Fang, R Sun, B Liu - Journal of Medicinal Chemistry, 2024
The molecular origin of the sweet taste is still elusive. Herein, the canonical AH-BX
theory of sweet taste is extended by resurveying various sweeteners, which provides
deeper insights into an analogous intramolecular connectivity pattern of both
glucophores in sweeteners and their interaction counterparts in sweet taste receptor
TAS1R2/TAS1R3: electrostatic complementarity and topochemical compatibility.
Furthermore, their complementary interaction is elaborately illustrated, accounting for …
theory of sweet taste is extended by resurveying various sweeteners, which provides
deeper insights into an analogous intramolecular connectivity pattern of both
glucophores in sweeteners and their interaction counterparts in sweet taste receptor
TAS1R2/TAS1R3: electrostatic complementarity and topochemical compatibility.
Furthermore, their complementary interaction is elaborately illustrated, accounting for …
| • | 引用: Structural basis for perception of diverse chemical substances by … |
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[PDF] New targets of nascent lymphatic vessels in ocular diseases
X Wu, Y Ma - Frontiers in Physiology, 2024
Recent advancements in the field of endothelial markers of lymphatic vessels and
lymphangiogenic factors have shed light on the association between several ocular
diseases and ocular nascent lymphatic vessels. The immune privilege of corneal
tissue typically limits the formation of lymphatic vessels in a healthy eye. However,
vessels in the eyes can potentially undergo lymphangiogenesis and be conditionally
activated. It is evident that nascent lymphatic vessels in the eyes contribute to various …
lymphangiogenic factors have shed light on the association between several ocular
diseases and ocular nascent lymphatic vessels. The immune privilege of corneal
tissue typically limits the formation of lymphatic vessels in a healthy eye. However,
vessels in the eyes can potentially undergo lymphangiogenesis and be conditionally
activated. It is evident that nascent lymphatic vessels in the eyes contribute to various …
| • | 引用: The effect of podoplanin inhibition on lymphangiogenesis under … |
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[HTML] The Perspectives of Platelet Proteomics in Health and Disease
PK Chaudhary, S Upadhayaya, S Kim, S Kim - Biomedicines, 2024
Cardiovascular thromboembolic diseases and cancer continue to be a leading cause
of death and disability worldwide. Therefore, it is crucial to advance their diagnoses
and treatment in the context of individualized medicine. However, the disease
specificity of the currently available markers is limited. Based on analyses of a subset
of peptides and matching proteins in disease vs. healthy platelets, scientists have
recently shown that focused platelet proteomics enables the quantification of disease …
of death and disability worldwide. Therefore, it is crucial to advance their diagnoses
and treatment in the context of individualized medicine. However, the disease
specificity of the currently available markers is limited. Based on analyses of a subset
of peptides and matching proteins in disease vs. healthy platelets, scientists have
recently shown that focused platelet proteomics enables the quantification of disease …
| • | 引用: Molecular analysis of the pathophysiological binding of the platelet  |