Epitope Mapping of an Anti-mouse CCR8 Monoclonal Antibody C8Mab-2 Using Flow Cytometry
H Kobayashi, H Suzuki, T Tanaka, MK Kaneko, Y Kato - 2024
The CC motif chemokine receptor 8 (CCR8) is highly and selectively expressed in
regulatory T (Treg) cells and is associated with tumor progression. The massive
accumulation of Treg cells into tumors suppresses the effector function of CD8+ cells
against tumor cells. Therefore, selective depletion of Treg cells using anti-CCR8
monoclonal antibodies (mAbs) reinvigorates antitumor immune responses and
improves responses to cancer immunotherapy. Previously, we developed an anti …
regulatory T (Treg) cells and is associated with tumor progression. The massive
accumulation of Treg cells into tumors suppresses the effector function of CD8+ cells
against tumor cells. Therefore, selective depletion of Treg cells using anti-CCR8
monoclonal antibodies (mAbs) reinvigorates antitumor immune responses and
improves responses to cancer immunotherapy. Previously, we developed an anti …
| • | 引用: Epitope Mapping of Anti-Mouse CCR3 Monoclonal Antibodies …  |
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[HTML] The regulations of telomerase reverse transcriptase (TERT) in cancer
M Liu, Y Zhang, Y Jian, L Gu, D Zhang, H Zhou… - Cell Death & Disease, 2024
Abnormal activation of telomerase occurs in most cancer types, which facilitates
escaping from cell senescence. As the key component of telomerase, telomerase
reverse transcriptase (TERT) is regulated by various regulation pathways. TERT
gene changing in its promoter and phosphorylation respectively leads to TERT
ectopic expression at the transcription and protein levels. The co-interacting factors
play an important role in the regulation of TERT in different cancer types. In this …
escaping from cell senescence. As the key component of telomerase, telomerase
reverse transcriptase (TERT) is regulated by various regulation pathways. TERT
gene changing in its promoter and phosphorylation respectively leads to TERT
ectopic expression at the transcription and protein levels. The co-interacting factors
play an important role in the regulation of TERT in different cancer types. In this …
| • | 引用: Phosphorylation of hTERT at threonine 249 is a novel tumor … |
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Prevalence and implications of pKs-positive Escherichia coli in colorectal cancer
JB de Souza, LA de Almeida Campos, SB Palácio… - Life Sciences, 2024
Colorectal cancer (CRC) remains a significant global health concern, necessitating
continuous investigation into its etiology and potential risk factors. Recent research
has shed light on the potential role of pKs-positive Escherichia coli (pKs+ E. coli) and
colibactin in the development and progression of CRC. Therefore, this review aimed
to provide an updated analysis of the prevalence and implications of pKs+ E. coli in
colorectal cancer. We conducted a literature review search in major scientific …
continuous investigation into its etiology and potential risk factors. Recent research
has shed light on the potential role of pKs-positive Escherichia coli (pKs+ E. coli) and
colibactin in the development and progression of CRC. Therefore, this review aimed
to provide an updated analysis of the prevalence and implications of pKs+ E. coli in
colorectal cancer. We conducted a literature review search in major scientific …
| • | 引用: Antitumor activities of a defucosylated anti‑EpCAM monoclonal … |
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Emergence of sweet Ligand-Protein complexes from seemingly non-sweet conformations
E Kashani-Amin, J Alizadeh-Rahrovi, A Sadri… - Journal of Molecular Liquids, 2024
Sweet taste perception starts from the interaction of a sweet molecule with residues
of the sweet taste receptor (STR). Yet, how the perception of sweet taste emerges
from this interaction is still not clear. Here, we reveal a potential mechanism in the
initial stages of this cascade. In our previous studies, we observed a 0.6 Pearson
correlation coefficient between binding affinity and sweetness intensity. We
conducted a series of MD simulations by YASARA Structure, for a total of 1.8 …
of the sweet taste receptor (STR). Yet, how the perception of sweet taste emerges
from this interaction is still not clear. Here, we reveal a potential mechanism in the
initial stages of this cascade. In our previous studies, we observed a 0.6 Pearson
correlation coefficient between binding affinity and sweetness intensity. We
conducted a series of MD simulations by YASARA Structure, for a total of 1.8 …
| • | 引用: Structural basis for perception of diverse chemical substances by … |
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Expression of molecular markers and synergistic anticancer effects of chemotherapy with antimicrobial peptides on glioblastoma cells
AN Chernov, AV Kim, SS Skliar, EV Fedorov… - Cancer Chemotherapy and …, 2024
Objective Glioblastoma multiforme (GBM) is the most aggressive and fatal malignant
primary brain tumor. The enhancement of the survival rate for glioma patients
remains limited, even with the utilization of a combined treatment approach involving
surgery, radiotherapy, and chemotherapy. This study was designed to assess the
expression of IDH1, TP53, EGFR, Ki-67, GFAP, H3K27M, MGMT, VEGF, NOS, CD99,
and ATRX in glioblastoma tissue from 11 patients. We investigated the anticancer …
primary brain tumor. The enhancement of the survival rate for glioma patients
remains limited, even with the utilization of a combined treatment approach involving
surgery, radiotherapy, and chemotherapy. This study was designed to assess the
expression of IDH1, TP53, EGFR, Ki-67, GFAP, H3K27M, MGMT, VEGF, NOS, CD99,
and ATRX in glioblastoma tissue from 11 patients. We investigated the anticancer …
| • | 引用: Immunohistochemistry on IDH 1/2, ATRX, p53 and Ki-67 substitute … |