The interplay between Natural Killer cells and Pancreatic Stellate cells in Pancreatic Ductal Adenocarcinoma
R Fincham - 2024
Pancreatic ductal adenocarcinoma (PDAC) is a disease with dismal prognosis. With
five-year survival rates of less than 11%, PDAC is set to become the second leading
cause of cancer related deaths by 2040. The role of pancreatic stellate cells in
pancreatic ductal adenocarcinoma has been well established. However, to date, little
remains know about the interaction between these crucial stromal cells and the
innate lymphocytes, natural killer (NK) cells, in PDAC. Herein we demonstrate that …
five-year survival rates of less than 11%, PDAC is set to become the second leading
cause of cancer related deaths by 2040. The role of pancreatic stellate cells in
pancreatic ductal adenocarcinoma has been well established. However, to date, little
remains know about the interaction between these crucial stromal cells and the
innate lymphocytes, natural killer (NK) cells, in PDAC. Herein we demonstrate that …
| • | 引用: Roles of podoplanin in malignant progression of tumor  |
 |
 |
 |
 |
[HTML] The Multifaceted Roles of NRF2 in Cancer: Friend or Foe?
C Glorieux, C Enríquez, C González… - Antioxidants, 2024
Physiological concentrations of reactive oxygen species (ROS) play vital roles in
various normal cellular processes, whereas excessive ROS generation is central to
disease pathogenesis. The nuclear factor erythroid 2-related factor 2 (NRF2) is a
critical transcription factor that regulates the cellular antioxidant systems in response
to oxidative stress by governing the expression of genes encoding antioxidant
enzymes that shield cells from diverse oxidative alterations. NRF2 and its negative …
various normal cellular processes, whereas excessive ROS generation is central to
disease pathogenesis. The nuclear factor erythroid 2-related factor 2 (NRF2) is a
critical transcription factor that regulates the cellular antioxidant systems in response
to oxidative stress by governing the expression of genes encoding antioxidant
enzymes that shield cells from diverse oxidative alterations. NRF2 and its negative …
| • | 引用: BACH1 promotes pancreatic cancer metastasis by repressing … |
|
|
|
|
[HTML] Investigating Cox-2 and EGFR as Biomarkers in Canine Oral Squamous Cell Carcinoma: Implications for Diagnosis and Therapy
R Files, C Santos, FL Queiroga, F Silva, L Delgado… - Current Issues in Molecular …, 2024
Oral squamous cell carcinoma (OSCC) is a common and highly aggressive dog
tumor known for its local invasiveness and metastatic potential. Understanding the
molecular mechanisms driving the development and progression of OSCC is crucial
for improving diagnostic and therapeutic strategies. Additionally, spontaneous oral
squamous cell carcinomas in dogs are an excellent model for studying human
counterparts. In this study, we aimed to investigate the significance of two key …
tumor known for its local invasiveness and metastatic potential. Understanding the
molecular mechanisms driving the development and progression of OSCC is crucial
for improving diagnostic and therapeutic strategies. Additionally, spontaneous oral
squamous cell carcinomas in dogs are an excellent model for studying human
counterparts. In this study, we aimed to investigate the significance of two key …
| • | 引用: A novel anti‑EGFR monoclonal antibody (EMab‑17) exerts … |
|
|
|
|
The utility of arterial spin labeling imaging for predicting prognosis after a recurrence of high-grade glioma in patients under bevacizumab treatment
A Kambe, S Kitao, R Ochiai, T Hosoya, S Fujii… - Journal of Neuro-Oncology, 2024
Background and purpose Currently, the antiangiogenic agent bevacizumab (BVZ) is
used as a treatment option for high-grade glioma (HGG) patients. However, BVZ
restores disruptions of the blood–brain barrier, which leads to the disappearance of
contrast enhancement during radiological examinations and therefore complicates
evaluations of treatment efficacy. This study aimed to investigate the radio-
morphological features of recurrent lesions that newly appeared under BVZ therapy …
used as a treatment option for high-grade glioma (HGG) patients. However, BVZ
restores disruptions of the blood–brain barrier, which leads to the disappearance of
contrast enhancement during radiological examinations and therefore complicates
evaluations of treatment efficacy. This study aimed to investigate the radio-
morphological features of recurrent lesions that newly appeared under BVZ therapy …
| • | 引用: Immunohistochemical detection of IDH1 mutation, p53, and …  |