Chlorinated Enyne Fatty Acid Amides from a Marine Cyanobacterium: Discovery of Taveuniamides LM and Pharmacological Characterization of Taveuniamide F as a …
LA Elsadek, EK Ellis, G Seabra, VJ Paul, H Luesch - Marine Drugs, 2023
NMR and MS/MS-based metabolomics of a cyanobacterial extract from Piti Bomb
Holes, Guam, indicated the presence of unique enyne-containing halogenated fatty
acid amides. We isolated three new compounds of this class, taveuniamides LN (1–
3), along with the previously reported taveuniamide F (4), which was the most
abundant analog. The planar structures of the new compounds were established
using 1D and 2D NMR as well as mass spectrometry. We established the …
Holes, Guam, indicated the presence of unique enyne-containing halogenated fatty
acid amides. We isolated three new compounds of this class, taveuniamides LN (1–
3), along with the previously reported taveuniamide F (4), which was the most
abundant analog. The planar structures of the new compounds were established
using 1D and 2D NMR as well as mass spectrometry. We established the …
| • | 引用: Development of anti-human CC chemokine receptor 9 monoclonal …  |
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Diphenyl-tetrazol-propanamide Derivatives Act as Dual-Specific Antagonists of Platelet CLEC-2 and Glycoprotein VI
N Watanabe, Y Shinozaki, S Ogiwara, R Miyagasako… - Thrombosis and …, 2023
Background Platelet C-type lectin-like receptor 2 (CLEC-2) induces platelet
activation and aggregation after clustering by its ligand podoplanin (PDPN). PDPN,
which is not normally expressed in cells in contact with blood flow, is induced in
inflammatory immune cells and some malignant tumor cells, thereby increasing the
risk of venous thromboembolism (VTE) and tumor metastasis. Therefore, small-
molecule compounds that can interfere with the PDPN–CLEC-2 axis have the …
activation and aggregation after clustering by its ligand podoplanin (PDPN). PDPN,
which is not normally expressed in cells in contact with blood flow, is induced in
inflammatory immune cells and some malignant tumor cells, thereby increasing the
risk of venous thromboembolism (VTE) and tumor metastasis. Therefore, small-
molecule compounds that can interfere with the PDPN–CLEC-2 axis have the …
| • | 引用: Roles of podoplanin in malignant progression of tumor |
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[PDF] Humanization of Chimeric Antigen Receptors (CARs) OSCAR-1 and OSCAR-3
P Ahnstrøm - 2023
Osteosarcoma (OS), a malignant tumor of the bone, is one of the most common forms
of cancer among adolescence, presenting in more than 5 per 1 million children
under 15 years of age. The occurrence of OS has a bimodal distribtion across age
groups: While the incidence peak worldwide is around pubertal growth spurt, the
occurrence rate increases again around the age of 60 years. Generally, men are
more affected than women, and this trend is even more prominent in the elderly1 …
of cancer among adolescence, presenting in more than 5 per 1 million children
under 15 years of age. The occurrence of OS has a bimodal distribtion across age
groups: While the incidence peak worldwide is around pubertal growth spurt, the
occurrence rate increases again around the age of 60 years. Generally, men are
more affected than women, and this trend is even more prominent in the elderly1 …
| • | 引用: Improved anti‐solid tumor response by humanized anti … |
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[HTML] Fucoidan's Molecular Targets: A Comprehensive Review of Its Unique and Multiple Targets Accounting for Promising Bioactivities Supported by In Silico Studies
A Zayed, DA Al-Saedi, EO Mensah, ON Kanwugu… - Marine Drugs, 2023
Fucoidan is a class of multifunctional polysaccharides derived from marine
organisms. Its unique and diversified physicochemical and chemical properties have
qualified them for potential and promising pharmacological uses in human diseases,
including inflammation, tumors, immunity disorders, kidney diseases, and diabetes.
Physicochemical and chemical properties are the main contributors to these
bioactivities. The previous literature has attributed such activities to its ability to target …
organisms. Its unique and diversified physicochemical and chemical properties have
qualified them for potential and promising pharmacological uses in human diseases,
including inflammation, tumors, immunity disorders, kidney diseases, and diabetes.
Physicochemical and chemical properties are the main contributors to these
bioactivities. The previous literature has attributed such activities to its ability to target …
| • | 引用: A platform of C-type lectin-like receptor CLEC-2 for binding O … |
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[HTML] Near-infrared-II Ag2S quantum dot probes targeting podoplanin enhance immunotherapy in oral squamous cell carcinoma
H Xiong, S Shao, Y Yang, W Wang, H Xiong, Y Han… - Biomedicine & …, 2024
Partial epithelial-mesenchymal transition (pEMT) plays a vital role in oral squamous
cell carcinoma (OSCC) cervical lymph node metastasis and tumor immune escape
as an immune barrier. However, targeted interventions for pEMT have yet to be
established. In this study, we generated an αPDPN-Ag 2 S probe by modifying a
Podoplanin (PDPN) monoclonal antibody on the surface of near infrared (NIR)-II Ag
2 S quantum dots (QDs) with carboxyl groups through an amide reaction. Then, we …
cell carcinoma (OSCC) cervical lymph node metastasis and tumor immune escape
as an immune barrier. However, targeted interventions for pEMT have yet to be
established. In this study, we generated an αPDPN-Ag 2 S probe by modifying a
Podoplanin (PDPN) monoclonal antibody on the surface of near infrared (NIR)-II Ag
2 S quantum dots (QDs) with carboxyl groups through an amide reaction. Then, we …
| • | 引用: CAR T cells targeting podoplanin reduce orthotopic glioblastomas … |
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Human pangenome: far-reaching implications in precision medicine
Y Yu, H Chen - Frontiers of Medicine, 2023
On May 11, 2023, the internationally renowned journal Nature announced that a first
draft of the human pangenome reference has been constructed [1]. This research
was carried out by the Human Pangenome Reference Consortium (HPRC). One
month later, on June 14, 2023, a pangenome reference of 36 Chinese populations
was published on journal Nature [2], which was performed by Chinese Pangenome
Consortium (CPC). As the scientists pointed out that since the Human Genome …
draft of the human pangenome reference has been constructed [1]. This research
was carried out by the Human Pangenome Reference Consortium (HPRC). One
month later, on June 14, 2023, a pangenome reference of 36 Chinese populations
was published on journal Nature [2], which was performed by Chinese Pangenome
Consortium (CPC). As the scientists pointed out that since the Human Genome …
| • | 引用: Deletion polymorphism of SIGLEC14 and its functional implications  |