Prognostic impact of cytoplasmatic EGFR upregulation in patients with oral squamous cell carcinoma: A pilot study
M Kappler, K Dauter, W Reich, D Bethmann… - Molecular and Clinical …, 2020
In various tumors, epidermal growth factor‑receptor (EGFR) serves a role in
tumorigenesis and has an impact on survival. Usually the EGF‑receptor is located on
the surface of the cell membrane and is involved in various signaling pathways. The
dimerization of EGFR with other ErbB family proteins, such as HER2, is important for
the tumor progression. Nevertheless, a second EGFR‑associated signaling pathway
appears to be important for tumor cells, which is cytoplasmic/nuclear EGFR. The …
tumorigenesis and has an impact on survival. Usually the EGF‑receptor is located on
the surface of the cell membrane and is involved in various signaling pathways. The
dimerization of EGFR with other ErbB family proteins, such as HER2, is important for
the tumor progression. Nevertheless, a second EGFR‑associated signaling pathway
appears to be important for tumor cells, which is cytoplasmic/nuclear EGFR. The …
| • | 引用: A novel anti‑EGFR monoclonal antibody (EMab‑17) exerts …  |
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Microdevice immunoassay with conjugated magnetic nanoparticles for rapid anti-cyclic citrullinated peptide (anti-CCP) detection
KC Ramos, MPC Macías - Talanta, 2020
Anti-cyclic citrullinated peptide IgG antibodies (anti-CCP) are produced as an
immune response in the presence of post-translational modified peptides known as
cyclic citrullinated peptides (CCP). Anti-CCP have been considered as specific
biomarkers for the diagnosis of rheumatoid arthritis (RA), and due to their high
specificity, it is possible to make a differential diagnosis of other rheumatic diseases.
These autoantibodies can be detected in the early stages of RA and even up to 10 …
immune response in the presence of post-translational modified peptides known as
cyclic citrullinated peptides (CCP). Anti-CCP have been considered as specific
biomarkers for the diagnosis of rheumatoid arthritis (RA), and due to their high
specificity, it is possible to make a differential diagnosis of other rheumatic diseases.
These autoantibodies can be detected in the early stages of RA and even up to 10 …
| • | 引用: An immuno-wall microdevice exhibits rapid and sensitive … |
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[PDF] Evidence that Maackia amurensis seed lectin (MASL) exerts pleiotropic actions on oral squamous cells to inhibit SARS-CoV-2 infection and COVID-19 disease …
SA Sheehan, KL Hamilton, EP Retzbach… - 2020
COVID-19 was declared an international public health emergency in January, and a
pandemic in March of 2020. There are over 23 million confirmed COVID-19 cases
that have cause over 800 thousand deaths worldwide as of August 19th, 2020.
COVID-19 is caused by the SARS-CoV-2 virus. SARS-CoV-2 presents a surface
“spike” protein that binds to the ACE2 receptor to infect host cells. In addition to the
respiratory tract, SARS-Cov-2 can also infect cells of the oral mucosa, which also …
pandemic in March of 2020. There are over 23 million confirmed COVID-19 cases
that have cause over 800 thousand deaths worldwide as of August 19th, 2020.
COVID-19 is caused by the SARS-CoV-2 virus. SARS-CoV-2 presents a surface
“spike” protein that binds to the ACE2 receptor to infect host cells. In addition to the
respiratory tract, SARS-Cov-2 can also infect cells of the oral mucosa, which also …
| • | 引用: Antibody and lectin target podoplanin to inhibit oral … |
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[PDF] The anti‑epithelial cell adhesion molecule (EpCAM) monoclonal antibody EpMab‑16 exerts antitumor activity in a mouse model of colorectal adenocarcinoma
H Hosono, T Ohishi, J Takei, T Asano, Y Sayama… - Oncology Letters, 2020
The epithelial cell adhesion molecule (EpCAM), which is a calcium‑independent
homophilic intercellular adhesion factor, contributes to cell signaling, differentiation,
proliferation and migration. EpCAM is essential for carcinogenesis in numerous
types of human cancer. The purpose of the present study was to establish an anti‑
EpCAM monoclonal antibody (mAb) for targeting colorectal adenocarcinomas. Thus,
an anti‑EpCAM mAb, EpMab‑16 (IgG2a, κ), was established by immunizing mice with …
homophilic intercellular adhesion factor, contributes to cell signaling, differentiation,
proliferation and migration. EpCAM is essential for carcinogenesis in numerous
types of human cancer. The purpose of the present study was to establish an anti‑
EpCAM monoclonal antibody (mAb) for targeting colorectal adenocarcinomas. Thus,
an anti‑EpCAM mAb, EpMab‑16 (IgG2a, κ), was established by immunizing mice with …
| • | 引用: An Anti-Human Epidermal Growth Factor Receptor 2 … |
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[PDF] Development of Core-Fucose-Deficient Humanized and Chimeric Anti-Human Podoplanin Antibodies
MK Kaneko, T Ohishi, T Nakamura, H Inoue, J Takei… - Monoclonal Antibodies in …, 2020
Podoplanin (PDPN), a 36-kDa type I transmembrane O-glycoprotein, is expressed in
normal cells, including renal epithelial cells (podocytes), lymphatic endothelial cells,
and pulmonary type I alveolar cells, and in cancer cells, including brain tumors and
squamous cell lung carcinomas. PDPN activates platelet aggregation by binding to C-
type lectin-like receptor-2 (CLEC-2) on platelets, and PDPN/CLEC-2 interaction
facilitates blood/lymphatic vessel separation. We previously produced an anti-human …
normal cells, including renal epithelial cells (podocytes), lymphatic endothelial cells,
and pulmonary type I alveolar cells, and in cancer cells, including brain tumors and
squamous cell lung carcinomas. PDPN activates platelet aggregation by binding to C-
type lectin-like receptor-2 (CLEC-2) on platelets, and PDPN/CLEC-2 interaction
facilitates blood/lymphatic vessel separation. We previously produced an anti-human …
| • | 引用: Therapeutic efficacy evaluation of radioimmunotherapy with … |