[PDF] Pathways for Sensing and Responding to Hydrogen Peroxide at the Endoplasmic Reticulum
JM Roscoe, CS Sevier - Cells, 2020
The endoplasmic reticulum (ER) has emerged as a source of hydrogen peroxide (H
2 O 2) and a hub for peroxide-based signaling events. Here we outline cellular
sources of ER-localized peroxide, including sources within and near the ER.
Focusing on three ER-localized proteins—the molecular chaperone BiP, the
transmembrane stress-sensor IRE1, and the calcium pump SERCA2—we discuss
how post-translational modification of protein cysteines by H 2 O 2 can alter ER …
2 O 2) and a hub for peroxide-based signaling events. Here we outline cellular
sources of ER-localized peroxide, including sources within and near the ER.
Focusing on three ER-localized proteins—the molecular chaperone BiP, the
transmembrane stress-sensor IRE1, and the calcium pump SERCA2—we discuss
how post-translational modification of protein cysteines by H 2 O 2 can alter ER …
| • | 引用: Structural basis of sarco/endoplasmic reticulum Ca2+ …  |
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[PDF] Outer Membrane Vesicles From Brucella melitensis Modulate Immune Response and Induce Cytoskeleton Rearrangement in Peripheral Blood Mononuclear Cells
ED Avila-Calderón, O Medina-Chávez, L Flores-Romo… - Frontiers in Microbiology, 2020
Avila-Calderón et al. B. melitensis Outer Membrane Vesicles in OMVs from B.
melitensis16M, and 43 in OMVs from B. melitensis VTRM1. Proteome comparison
showed that 22 orthologous proteins were common in vesicles from both strains, and
their core proteome contained Omp31, Omp25, GroL, and Omp16. After a
subsequent detergent and enzyme treatment, OMVs from B. melitensis VTRM1
exhibited higher sensitive compared to OMVs from the B. melitensis 16M strain …
melitensis16M, and 43 in OMVs from B. melitensis VTRM1. Proteome comparison
showed that 22 orthologous proteins were common in vesicles from both strains, and
their core proteome contained Omp31, Omp25, GroL, and Omp16. After a
subsequent detergent and enzyme treatment, OMVs from B. melitensis VTRM1
exhibited higher sensitive compared to OMVs from the B. melitensis 16M strain …
| • | 引用: Increase of cells expressing PD‐1 and PD‐L1 and … |
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Increased programmed death ligand (PD-L1) and cytotoxic T-lymphocyte antigen-4 (CTLA-4) expression is associated with metastasis and poor prognosis in …
H Ariyarathna, NA Thomson, D Aberdein, MR Perrott… - Veterinary Immunology and …, 2020
Aberrant expression of immune check point molecules, programmed death ligand
(PD-L1) and cytotoxic T-lymphocyte antigen-4 (CTLA-4) has been reported in many
human cancers with increased protein and gene expression correlated with an
aggressive behaviour in some neoplasms. Additionally, PD-L1 blockade has been
shown to be an effective therapy for some human cancers. Canine mammary gland
tumours have previously been shown to produce PD-L1 protein, but there are no …
(PD-L1) and cytotoxic T-lymphocyte antigen-4 (CTLA-4) has been reported in many
human cancers with increased protein and gene expression correlated with an
aggressive behaviour in some neoplasms. Additionally, PD-L1 blockade has been
shown to be an effective therapy for some human cancers. Canine mammary gland
tumours have previously been shown to produce PD-L1 protein, but there are no …
| • | 引用: A canine chimeric monoclonal antibody targeting PD-L1 and … |
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[PDF] Eziologia dei tumori
ALEBG DEI TUMORI
I tessuti e gli organi normali contengono una quantità differente di cellule staminali
che mantengono l'omeostasi. Le cellule staminali possiedono la capacità di
autorinnovarsi e di vivere più a lungo rispetto alle altre cellule residenti del tessuto,
le quali vengono sostituite per mantenere la struttura e la funzione normali
dell'organo. Studi recenti condotti da Tomasetti e Vogelstein hanno identificato una
forte correlazione (r= 0, 81) tra il numero totale di divisioni cellulari di cellule …
che mantengono l'omeostasi. Le cellule staminali possiedono la capacità di
autorinnovarsi e di vivere più a lungo rispetto alle altre cellule residenti del tessuto,
le quali vengono sostituite per mantenere la struttura e la funzione normali
dell'organo. Studi recenti condotti da Tomasetti e Vogelstein hanno identificato una
forte correlazione (r= 0, 81) tra il numero totale di divisioni cellulari di cellule …
| • | 引用: A canine chimeric monoclonal antibody targeting PD-L1 and … |
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[HTML] Escape from abluminal LRP1-mediated clearance for boosted nanoparticle brain delivery and brain metastasis treatment
NU Khan, J Ni, X Ju, T Miao, H Chen, L Han - Acta Pharmaceutica Sinica B, 2020
Breast cancer brain metastases (BCBMs) are one of the most difficult malignancies to
treat due to the intracranial location and multifocal growth. Chemotherapy and
molecular targeted therapy are extremely ineffective for BCBMs due to the inept brain
accumulation because of the formidable blood‒brain barrier (BBB). Accumulation
studies prove that low density lipoprotein receptor-related protein 1 (LRP1) is
promising target for BBB transcytosis. However, as the primary clearance receptor for …
treat due to the intracranial location and multifocal growth. Chemotherapy and
molecular targeted therapy are extremely ineffective for BCBMs due to the inept brain
accumulation because of the formidable blood‒brain barrier (BBB). Accumulation
studies prove that low density lipoprotein receptor-related protein 1 (LRP1) is
promising target for BBB transcytosis. However, as the primary clearance receptor for …
| • | 引用: The role of MMP-1 in breast cancer growth and metastasis to … |