Illuminating the allosteric modulation of the calcium-sensing receptor
H Liu, P Yi, W Zhao, Y Wu, F Acher, JP Pin, J Liu… - Proceedings of the National …, 2020
Many membrane receptors are regulated by nutrients. However, how these nutrients
control a single receptor remains unknown, even in the case of the well-studied
calcium-sensing receptor CaSR, which is regulated by multiple factors, including …
control a single receptor remains unknown, even in the case of the well-studied
calcium-sensing receptor CaSR, which is regulated by multiple factors, including …
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[PDF] Isocitrate Dehydrogenase Mutations in Glioma: Genetics, Biochemistry, and Clinical Indications
Y Liu, F Lang, FJ Chou, KA Zaghloul, C Yang - Biomedicines, 2020
Mutations in isocitrate dehydrogenase (IDH) are commonly observed in lower-grade
glioma and secondary glioblastomas. IDH mutants confer a neomorphic enzyme
activity that converts α-ketoglutarate to an oncometabolite D-2-hydroxyglutarate …
glioma and secondary glioblastomas. IDH mutants confer a neomorphic enzyme
activity that converts α-ketoglutarate to an oncometabolite D-2-hydroxyglutarate …
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Therapeutic targeting of OLIG2 in high grade glioma
S CHEN - 2020
CT-179 is a world first, small molecule drug designated for specific targeting of a
transcription factor named OLIG2. This thesis investigates the working mechanism
and efficacy of CT-179 for the treatment of the most malignant brain tumour …
transcription factor named OLIG2. This thesis investigates the working mechanism
and efficacy of CT-179 for the treatment of the most malignant brain tumour …