可能な限り他に薬で対応しようとしても ステロイド剤以外に有効な治療方法のない疾患は沢山あります。
ブデソニドは 他にステロイドと代謝経路が違うので、全身性の副作用が出にくいですが、残念ならが日本では
喘息の吸入剤しか手に入りません。人間でも必要な人は個人的に輸入して使っているようでが当院でもステロイドの副作用が重度な症例に限り使用しています。早く国内で発売されることを願います。
以下 犬の炎症性腸炎 ブデソニドを使って副作用が改善された ペーパーです
Tumulty JW, Broussard JD, Steiner JM, Peterson ME, Williams DA.
The Animal Medical Center, E & M Bobst Hospital, Caspary Research Institute, New York, New York 10021-8314, USA.
Six dogs were entered into a 30-day, prospective, nonrandomized, uncontrolled clinical trial evaluating the effects of an oral preparation of budesonide on the hypothalamic-pituitary-adrenal (HPA) axis during therapeutic management of active inflammatory bowel disease. Oral budesonide, at a dose of 3 mg/m(2), was administered once daily. Upon entry and completion of the trial, serum basal cortisol, adrenocorticotropic (ACTH)-stimulated cortisol, endogenous ACTH concentration, serum alkaline phosphatase (SAP) activity, and urine specific gravity were evaluated, as well as owner assessment of glucocorticoid-associated side effects. Significant suppression of the HPA axis occurred. No significant differences in SAP activity, urine specific gravity, or owner-subjective assessments were detected
