Cenforce 100 mg should be taken as directed by your doctor. Follow your doctor's directions. Doing so could lead to undesirable side effects. Follow the directions when taking Cenforce 150. You can take it orally with a glass water. You should swallow the entire thing. It is okay to take the drug without food, but it is best to swallow the entire thing. Cenforce 150mg should be taken 30-60 minutes prior to any sexual activity.