Name : Liposomal Silybin
Specification : 50%
Appearance : Light yellow powder
CAS. No. : 22888-70-6
Challenges with Conventional Silybin
Silybin is primarily taken orally but has low solubility, low permeability and poor bioavailability. Approximately 20% to 50% of its active components are absorbed after oral administration, with about 80% secreted via bile and 10% entering the enterohepatic circulation, resulting in low oral bioavailability.
Liposomal Silybin Cas 22888-70-6
liposomal extract are microvesicles composed of lipid bilayers, with a hydrophilic exterior and a lipophilic core. This unique structure allows them to encapsulate both water-soluble and lipid-soluble substances. Importantly, the bilayer structure of liposomes is similar to that of human cell membranes, enabling them to easily cross cell membranes. Formulating silybin silymarin into liposomes can significantly enhance its bioavailability.
Numerous pharmacokinetic studies have shown that liposomal silymarin improve bioavailability in both healthy individuals and patients with chronic liver disease. Research indicates that silybin liposomal powder achieve over 10 times higher bioavailability compared to conventional silymarin tablets. Several studies in animals and humans have demonstrated that silybin milk thistle complexed with phosphatidylcholine exhibits superior bioavailability compared to non-complexed forms.
Efficacy of Liposomal Silybin Cas 22888-70-6
Antioxidant: Silybin's antioxidant effects are linked to phenolic antioxidants within cells, preventing free radical formation, scavenging free radicals, and inhibiting lipid peroxidation of membranes (regulating membrane permeability).
Anti-inflammatory: Silybin's anti-inflammatory effects are associated with the structure of various cells and their pathways.
Anti-fibrotic: silybin milk thistle extract exerts anti-fibrotic effects on the liver directly or indirectly.
Hepatocyte Membrane Protection: silybin and silymarin protects hepatocytes through multiple mechanisms, including binding to hepatocyte membrane proteins, inhibiting lipid peroxidation to stabilize membrane permeability, supporting the liver's synthesis of protective substances, and preventing damage from harmful substances.
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