HIFU puzzleChongqing, according to the mother mountain, the beautiful piece of land. In 'HIFU' famous Chongqing HIFU Technology Co., Ltd. (hereinafter referred to HIFU under) is located here. Company founder Zhibiao feel exactly adhere to independent innovation as the Straits to secure a piece of Feng Shui. Chongqing as a model of innovation, often meet here on visits to leaders of all levels of officials. Standing floor hall HIFU headquarters, Zhibiao facing a prototype with 'Entrepreneur' reporter Let's talk about the technical principles of the Straits. Hall on both sides of the wall, one side covered with various medals (including the highest award the medical device industry - National Technology Invention), the other side covered with government officials to visit the photo. Not tall, look fresh Zhibiao already explained this very masterfully. Zhibiao Lifelong proud HIFU focused ultrasound, claiming that without surgery, the doctor just in front of the computer little mouse that allows bone tumors, liver tumors, soft tissue tumors, breast cancer and other malignant and benign tumors such as uterine fibroids 'point to the disease', which has been the bone of this technique in the treatment of cancer patients survive a decade. With this innovation, Zhibiao honor plus body: Chongqing Medical University Medical Ultrasound Engineering Institute (National Key Laboratory of Ministry of National Science and Technology), director of the National Engineering Research Center of Digital the only approved medical devices - ultrasonic medical director of the National Engineering Research Center, School of Biomedical Engineering Dean Chongqing Medical University, the CPPCC National Committee. However Zhibiao of these honors and alleged miracle cures Strait Nike Air Max 2011 Men can not hide Nike KD VI Elite the dilemma on its market. In recent years, the causes of cancer death in our country the proportion of residents increased year by year, and has become the largest cause of death resident. According to the National Health Service survey data, from 1993 to 2005 of cancer patients increased by 115.5%. China's current new cancer patients each year about 1.6 million, the total number of patients cancer is about 4.5 million. According to the 'Daily Economic News' reported that in cancer therapy methods rely mainly on tumor interventional chemotherapy, tumor radiofrequency ablation, radioactive seed implants and other medical devices, according to one million yuan each device terminal price estimate, only these three products the potential market is up to 140 billion yuan. The market is quite substantial. But market since 1999, until 2006, HIFU revenue has remained at 20 million yuan from top to bottom, almost no growth. Even in 2009, when it sold 6 HIFU device. The Rotary was founded earlier than the sea and good shares (founded in 1996) in October 2011 at GEM, the same treatment to fight cancer signs, its own research and development of minimally invasive tumor treatment device (also used focused ultrasound principle) 2008 In 2011 the sales were 0.6988 million yuan, 103 million yuan, 154 million yuan and 195 million yuan, which is still only half good and not share revenue. Straits problem lies in where? Pain capital and capital as nightmarish first collaboration allows Zhibiao teams leave psychological shadow. 'We feel that we are engaged in scientific research, the need to introduce management, this is very clear.' Bouvet said deputy general manager of the Straits. Since March 1999 HIFU focused Nike Kids Sneakers ultrasound to get SFDA Medical Device Registration Certificate Soon, under the auspices of the Chongqing municipal government, the urgent need to boost the share price of technology subjects Shenzhen Overseas Chinese Town Group (hereinafter referred Nike Hyperdunk 2013 to as OCT) Investment HIFU 30 million yuan, accounting for 60% of the shares. Previously, the largest shareholder of Chongqing HIFU Medical University, Second Affiliated Hospital of its venture capital company, accounting for 88.89% of the shares, accounting for 11.11 percent R \u0026 D team. 'OCT incoming call to increase their investment, (diluted) Our team is only 3.89% of the shares.' Bouvet said. Started research and development team is not happy, Zhibiao eventually cause 'only the introduction of OCT to make the cake bigger' to convince the team. June 4, 1999, the two sides signed a cooperation agreement, from the sea to get help successful registration card less than three months. OCT sent an executive vice president, chief financial officer and a management committee composed Zhibiao. However, the honeymoon period will soon be over, the contradiction here. OCT wish to basic research and clinical studies returned to schools, hospitals, production Nike Air Max and sales and the company focused devices, so you can save large sums of money. Zhibiao think this is tantamount to Banded, because the operating HIFU machine train doctors have not yet matured, clinical program also needs to continue to improve, if at this time to cut basic research and clinical research, production and sales was devastating. When the animal experiments required cameras are not allowed to buy, both conflicts completely intensified. OCT decided to remove Zhibiao general manager position, changed into chief scientist, OCT new breed of general manager. Then chairman of Zhibiao that you do chief scientist, you mean what they say, the general manager to listen to you. 'I had a thorough understanding of what capital speak.' Bouvet said. When the board of directors announced the news to all employees, unexpected situation occurs, Straits dozen core technology team field resign. Finally, in the Chongqing municipal government matchmaker mediation, the two sides reached a settlement: Straits actively assist OCT full divestment soon as possible; this is not seen in the news media, without recourse to the law. At that time, OCT invested 30 million yuan has been spent 600 million yuan, which requires former shareholders bear. The best approach is from Chongqing Nike Barkley Posite Max Medical University, OCT direct the money back, then you can change the company's registered shareholders. President of Chongqing Medical University think so operations are not a problem, signed the agreement on behalf of the school, but to get the school to discuss the leadership, there are different opinions, 'Zhibiao not able to do, then let them buy it.' Opinions difficult unified, HIFU general meeting of shareholders, the other two shareholders see OCT gone, HIFU too risky, they are not willing to take. Thus, in the form of minutes of the meeting agreed Zhibiao team disk access. Zhibiao, Bouvet and other friends had to find the money to cobble together a patchwork, the deadline for the final hit OCT account one day. But soon other institutional shareholders still see the sea helped sales, take the national Cheap Nike Free Outlet prize, go back. '(2000) in March and April Strait up again when shareholders do not sign it, we want to bring the three points ...... Nike Air Max 2011 6 million yuan toss this thing a couple of years, HIFU or black households, not registered, can not be examined. 'Bouvet said. Until 2002, when a deputy mayor of Chongqing intervention HIFU OCT quit after only truly complete change of registered shareholders. After the Nike Air Max 2011 Men twists and turns, the team became the Straits Zhibiao really big shareholders, but they also delayed the market more than three years of trial and error time. Market weakness immature technology, marketing teams and powerful enough, what about the high growth? When Zhibiao help the team to become the real masters of the sea, they are left alone to face the market test. Prior to get permits, from the first case of bone tumors in clinical studies, one of more than a year, the team have been tried HIFU bone tumors, liver tumors, soft tissue tumors, breast cancer and other diseases, the Food and Drug Administration under the guidance of co 96 cases did a clinical study, HIFU approved indications only the four species. Get permits that year, 307 hospitals are Nike Air Max 2013 attracted to come to help buy the first product in the Taiwan Strait. HIFU target market position in the top three hospitals and Cancer Hospital, 307 Hospital outside, as well as 301 Hospital, Shanghai Tumor Hospital, Guangzhou Tumor Hospital and many other hospitals buy the Strait of products. Then two or three years, a series of seven or eight domestic companies to get the same registration card. In the Straits people, really be able to do ultrasound ablation, only HIFU, who followed the take-card business, but stole the name of the first HIFU technique is actually hyperthermia. 'This technology, because it is new, experts much, and know a lot of people is difficult to judge, so they are also planning for the ultrasound ablation.' Bouvet said. These companies get permits, the most well-known source Nike LeBron 11 of Germany called Beijing Biomedical Engineering Co., Ltd., is a NASDAQ listed company China Medical Technologies, Inc. subsidiary, GE has been in shares of the company, after exiting. Germany is now the source of this technology has been largely abandoned. With increasingly stringent regulatory, take half of the original card companies have not been able to get the registration card. In the eyes of the Straits, others hyperthermia, in the eyes of others, HIFU is also hyperthermia. When you hear the HIFU technology principle, a once hyperthermia technology industry experts into the country emerge out of the first sentence is, 'That's not that hyperthermia it? Already been made, is a kind of adjuvant therapy. 'In his view, if the Straits so unique really said to myself, why not send authoritative medical journal articles. In fact Zhibiao been working hard. He not only sold the equipment Churchill Hospital, Oxford University, hoping to seize the commanding heights of academic, HIFU also some clinical data published in the International Journal of ultrasound, and hosted the first international summit ultrasound treatment in 2001, again in 2010 Clinical Summit hosted by ultrasound. Shenyin Wanguo Securities and good stock for a written analysis report that the tumor minimally invasive treatment is the future trend, but now is not mature enough, is still exploring the development stage to aid therapy. Faced with the same market, the same 'immature technology' but why straits market growth far less and good stock? Bouvet that, first, compared to the new technology, doctors are more likely to choose a mature technology. 'Using HIFU products doctors need to HIFU corporate training two weeks or a month, after which the actual situation, HIFU and then decide whether to send a doctor to the scene to support.' Bouvet said. Second, because of breast cancer, liver cancer and other malignant tumors formation mechanism of different, different treatment options HIFU treatment in different hospitals. 'Malignant eliminate 99 percent, the result may Nike Air Jordan 4 Women have been a failure. If you want to completely eliminate finished, involving many issues.' Second Affiliated Hospital, a doctor told the 'entrepreneur' correspondent that he had done a comparison with their peers Clinical data HIFU center from other hospitals far from Second Affiliated Hospital of good. But he also knew, because the relationship between the Second Affiliated Hospital of the Straits, the data does not have enough credibility. Once again, the team is not powerful enough HIFU market and a single product. Unlike the monolithic technology team, the market leader has been changed, and now has a wealth of experience in financial straits before Jiang, general manager in charge of the steel market in 2009, Working at Heico only help. In the 'Entrepreneur' reporter the interview process, but also hear Straits of sales backbone to leave a message. Straits in 2011 the number of employees about 450 people, the sales team of 100 people, 22.2 percent of the total number of employees, the number of customers hospital its official website lists only a dozen. And with good stock in June 2011 with sales staff 271 people, accounting for 45% of the number of employees, its minimally invasive tumor treatment program has covered 39 tertiary Womens Nike LeBron 11 hospitals and 95 secondary hospitals. Scale Growth suspense finally found a heavy volume market, HIFU can be used to harvest more quickly it? Market stagnated, making 2006 Zhibiao their eyes locked on the treatment of uterine fibroids. 'Why are the main push Straits uterine fibroids? From the perspective of the doctor, the operation is relatively simple point, clinical use and promotion is relatively easier.' Second Affiliated Hospital, a doctor said, so it is for the hospital to lower, municipal hospitals, county hospitals can do, MCH provincial, city and county also can do. Using a lower threshold means that the scale of growth can be expected. Initially Haifu technical team and refused to give up cancer research has been carried out for nearly 10 years, a comprehensive strategic therapeutic areas to uterine fibroids. Zhibiao again convinced them: a disease first real breakthrough, do specification, can be accepted clinical medicine, and then go to break harder illness breast cancer, liver cancer, etc., are not completely abandoned. After the 2006 restructuring, HIFU quickly in 2007, a Singapore investment company more than 7000 million (20% of total shares), the company's valuation of about 300 million yuan, was preparing to go public. 2009 HIFU devices sold 6, 2010 12, 2012 17 Taiwan (revenue of about 100 million yuan), has maintained an annual growth of more than 30%. 'In this situation a few years, this strategy is right.' Bouvet said that in recent years sales of therapeutic products from uterine fibroids proportion of the total revenue of Kyo, 2011 have been accounted for NIKE KOBE IX Qi Cheng. Starting this year, non-invasive ultrasound ablation treatment of uterine fibroids project was also included in the Ministry of Science, 'second five' support projects, gynecologist Lang Jing and academicians as chief scientist on the project, with 29 hospitals nationwide to study together and promoting ultrasound ablation non-invasive treatment of uterine fibroids technology in clinical application and promotion. These patients all the information and data will be transmitted to the World Health Organization. Straits hope the next three years to lay its dominant position in the treatment of uterine fibroids. 'In recent years we have analyzed and summarized, an original and innovative industries, and in the end should have what links and content.' Zhibiao said. In the Strait of research with the system, the Biomedical Engineering Research Center is the company's Straits, Second Affiliated Hospital of the Clinical Center of the straits, both belonging to the hospital doctors also used HIFU. 'Three brands, a Sagittarius.' Bouvet said. 'Wang is the chairman, president, commander in chief, only in the institution, assured the staff, in order to ensure not offset direction.' 2009 years ago, a total of HIFU for research funding from a variety of countries in the nearly 2,000 Support yuan, after 2009, the efforts to support greater. While relying on government support all the way to the growth of HIFU not forget to appreciate, in the Straits original 'research use' before this growth model, coupled with a 'political' character. In 2010, a national leader visited the Straits, Straits prompted the birth of the hospital. Hospital next to the Straits of office, research and development building alterations made by the Straits. HIFU intends to market it as a model and a doctor training base. 'If we do not have a grasp of the HIFU focused ultrasound doctor, how do we promote it?' Jiang Gang said. Two sessions in 2012, as a member of the CPPCC National Committee Wang Zhibiao proposal again, wants the state to increase its support for original and innovative, Air Jordan Outlet often come to Beijing before him, to walk around the National Medical Insurance Association, hoping to HIFU focused ultrasound therapy into the national health insurance. Jiang Gang that countries should be more support such as the Straits original company, 'in the fight for national support, we good mental state.' In 2011, the Straits involved in carving up the National Natural Science Foundation of approximately $ 500 million. ' major scientific instrumentation 'project funds.