Velasof is a combination of velpatasvir 100 mg + sophosbuvir 400 mg. Velasof is a combination of two drugs for the treatment of hepatitis C. This is administered as a single daily tablet containing the viral velpatasvir inhibitor NS 5 A and sophosbuvir, a nucleotide inhibitor of the viral RNA polymerase . This Is The First Treatment That Works For All Genotypes, And Is Taken Entirely In The Mouth. A Single Pill Regimen Is Used For Adults With Genotype 1-6 Chronic Hepatitis CVirus (HCV) Infection With Pangenotypic Activity.