And on Wednesday the 28-year-old star got some more star power - in the form of a star on the Hollywood Walk Of Fame.
The blonde actress, who at one point was seen wiping away happy tears, was joined by the cast of her hit CBS show, who helped her celebrate the honour at the official unveiling ceremony.
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Cast members in attendance were Simon Helberg, Melissa Rauch, Johnny Galecki, Kaley, Jim Parsons and Kunal Nayyar.
Kaley's husband of ten months Ryan Sweeting also came along and gave his wife congratulatory kisses and hugs as the special slice of sidewalk was revealed.
Meanwhile, the Big Bang Theory's creator Chuck Lorre recently had kind words to say about the honoree's talent.
Star-spotting: Kaley also paid tribute to the later John Ritter, who died in 2003 and played her TV father of the comedy 8 Simple Rules
He told Variety, 'She has incredible skill as a comic actress that really can’t be taught.'
Lorre added: 'Her intuitive nature as to how to play a scene, plus all the experience she garnered on 8 Simple Rules, has made her very rich. She can do just about anything you ask of her as a writer, which is quite a gift.'
The talented star is currently locked into The Big Bang Theory until 2017, but she is already looking ahead.
Her co-stars: The actress celebrated with the cast of her hit CBS show including (left to right) Simon Helberg, Melissa Rauch, Johnny Galecki, Kaley, Jim Parsons and Kunal Nayyar
She has said, 'After the show, I don’t know if I’d want to do TV anymore. It’s extremely close to my heart, but I would love to move into movies.'
However, she appears to only have a desire to star in film and television and not make projects herself.
When asked if she has ever considered directing, her response was, 'I think my place is in front of the camera not behind, and I don’t know if that will ever change.'
Unlike many celebrities, Cuoco married outside of the entertainment industry. Her husband Ryan is a tennis player, who has been out of the professional circuit since 2012.
However, Kaley has the duo more than covered, with her $1 million per episode paycheck for her role as Penny on the eighth season of The Big Bang Theory, which recently switched from Mondays to Thursdays on CBS.
She is next set to star in comedy The Wedding Ringer - due out January 16 - with Olivia Thirlby, Josh Gad, and Kevin Hart.
Kaley also recently finished filming drama Burning Bodhi, with a 2015 scheduled release date. Know more about backless wedding dresses